5t0l: Difference between revisions

<table><tr><td colspan='2'>[[5t0l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T0L OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5T0L FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=73X:5-[4-(3,4-DICHLOROPHENYL)PIPERAZIN-1-YL]PYRIMIDINE-2,4-DIAMINE'>73X</scene>, <scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5t0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t0l OCA], [http://pdbe.org/5t0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t0l RCSB], [http://www.ebi.ac.uk/pdbsum/5t0l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t0l ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).