3ik0: Difference between revisions

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<StructureSection load='3ik0' size='340' side='right'caption='[[3ik0]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3ik0' size='340' side='right'caption='[[3ik0]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ik0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_a"_von_freudenreich_1890 "bacillus a" von freudenreich 1890]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3IK0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ik0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IK0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7C1:4-(4-METHYL-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BENZENECARBOXIMIDAMIDE'>7C1</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bzn|3bzn]], [[3bz0|3bz0]], [[3c06|3c06]], [[3c0a|3c0a]], [[3byx|3byx]], [[3ijz|3ijz]], [[3ik1|3ik1]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7C1:4-(4-METHYL-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BENZENECARBOXIMIDAMIDE'>7C1</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ik0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik0 OCA], [https://pdbe.org/3ik0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ik0 RCSB], [https://www.ebi.ac.uk/pdbsum/3ik0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ik0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3ik0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik0 OCA], [http://pdbe.org/3ik0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ik0 RCSB], [http://www.ebi.ac.uk/pdbsum/3ik0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ik0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA]] Provides the sole de novo source of dTMP for DNA biosynthesis.  
[https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus a von freudenreich 1890]]
[[Category: Lacticaseibacillus casei]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Thymidylate synthase]]
[[Category: Cancian L]]
[[Category: Cancian, L]]
[[Category: Costi MP]]
[[Category: Costi, M P]]
[[Category: Ferrari S]]
[[Category: Ferrari, S]]
[[Category: Leone R]]
[[Category: Leone, R]]
[[Category: Luciani R]]
[[Category: Luciani, R]]
[[Category: Mangani S]]
[[Category: Mangani, S]]
[[Category: Pozzi C]]
[[Category: Pozzi, C]]
[[Category: Methyltransferase]]
[[Category: Nucleotide biosynthesis]]
[[Category: Nucleotide synthase]]
[[Category: Transferase]]
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