5tjw: Difference between revisions

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<StructureSection load='5tjw' size='340' side='right'caption='[[5tjw]], [[Resolution|resolution]] 3.23&Aring;' scene=''>
<StructureSection load='5tjw' size='340' side='right'caption='[[5tjw]], [[Resolution|resolution]] 3.23&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5tjw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TJW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5TJW FirstGlance]. <br>
<table><tr><td colspan='2'>[[5tjw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/WSN/1933(H1N1)) Influenza A virus (A/WSN/1933(H1N1))] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TJW FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5tjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tjw OCA], [http://pdbe.org/5tjw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tjw RCSB], [http://www.ebi.ac.uk/pdbsum/5tjw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tjw ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.231&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tjw OCA], [https://pdbe.org/5tjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tjw RCSB], [https://www.ebi.ac.uk/pdbsum/5tjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tjw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/B4URF1_9INFA B4URF1_9INFA]] Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.[SAAS:SAAS00107710]  
[https://www.uniprot.org/uniprot/Q1K9H2_I33A0 Q1K9H2_I33A0] Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus (By similarity).[SAAS:SAAS002141_004_603280]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Hanke, L]]
[[Category: Vicugna pacos]]
[[Category: Knockenhauer, K E]]
[[Category: Hanke L]]
[[Category: Ploegh, H L]]
[[Category: Knockenhauer KE]]
[[Category: Schwartz, T U]]
[[Category: Ploegh HL]]
[[Category: Influenza]]
[[Category: Schwartz TU]]
[[Category: Inhibitory]]
[[Category: Nucleoprotein]]
[[Category: Vhh]]
[[Category: Viral protein-immune system complex]]
Retrieved from "https://proteopedia.org/5tjw"