5wcq: Difference between revisions

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<StructureSection load='5wcq' size='340' side='right'caption='[[5wcq]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
<StructureSection load='5wcq' size='340' side='right'caption='[[5wcq]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5wcq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WCQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WCQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[5wcq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevundimonas_diminuta Brevundimonas diminuta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WCQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WCQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.576&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5wcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wcq OCA], [http://pdbe.org/5wcq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wcq RCSB], [http://www.ebi.ac.uk/pdbsum/5wcq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wcq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wcq OCA], [https://pdbe.org/5wcq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wcq RCSB], [https://www.ebi.ac.uk/pdbsum/5wcq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wcq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OPD_BREDI OPD_BREDI] Has an unusual substrate specificity for synthetic organophosphate triesters and phosphorofluoridates. All of the phosphate triesters found to be substrates are synthetic compounds. The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease. It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate.


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Brevundimonas diminuta]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Campbell, E C]]
[[Category: Campbell EC]]
[[Category: Jackson, C J]]
[[Category: Jackson CJ]]
[[Category: Miton, C M]]
[[Category: Miton CM]]
[[Category: Tokuriki, N]]
[[Category: Tokuriki N]]
[[Category: Directed evolution]]
[[Category: Epistasis]]
[[Category: Hydrolase]]
[[Category: Laboratory evolution]]
[[Category: Organophosphate hydrolase]]
[[Category: Phosphotriesterase]]
Retrieved from "https://proteopedia.org/5wcq"