7k6c: Difference between revisions

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New page: '''Unreleased structure''' The entry 7k6c is ON HOLD until Paper Publication Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal Structure ...
 
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'''Unreleased structure'''


The entry 7k6c is ON HOLD  until Paper Publication
==Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium abscessus ATCC 19977 / DSM 44196 with NADP and inhibitor P218==
<StructureSection load='7k6c' size='340' side='right'caption='[[7k6c]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7k6c]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacteroides_abscessus_ATCC_19977 Mycobacteroides abscessus ATCC 19977]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K6C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K6C FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MMV:3-(2-{3-[(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)OXY]PROPOXY}PHENYL)PROPANOIC+ACID'>MMV</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k6c OCA], [https://pdbe.org/7k6c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k6c RCSB], [https://www.ebi.ac.uk/pdbsum/7k6c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k6c ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/B1MD46_MYCA9 B1MD46_MYCA9] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[PIRNR:PIRNR000194]


Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)
==See Also==
 
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
Description: Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium abscessus ATCC 19977 / DSM 44196 with NADP and inhibitor P218
__TOC__
[[Category: Unreleased Structures]]
</StructureSection>
[[Category: Seattle Structural Genomics Center For Infectious Disease (Ssgcid)]]
[[Category: Large Structures]]
[[Category: Mycobacteroides abscessus ATCC 19977]]
Retrieved from "https://proteopedia.org/7k6c"