Moesin: Difference between revisions
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<StructureSection load='4yl8' size=' | <StructureSection load='4yl8' size='400' side='right' caption='Mouse moesin FERM domain (green) complex with Crumbs C-terminal peptide (magenta), glycerol and I- ions (purple) (PDB code [[4yl8]]).' scene='86/864718/Cv/1'> | ||
== Function == | == Function == | ||
'''Moesin''' ('''M'''embrane-'''O'''rganizing '''E'''xtension '''S'''pike '''P'''rotein) is a member of the ERM family (Ezrin-Radixin-Moesin) which is important for organizing membrane domains of effector T cells<ref>PMID:28287407</ref>. | '''Moesin''' ('''M'''embrane-'''O'''rganizing '''E'''xtension '''S'''pike '''P'''rotein) is a member of the ERM family (Ezrin-Radixin-Moesin) which is important for organizing membrane domains of effector T cells<ref>PMID:28287407</ref>. It plays a role in modification of the actin cytoskeleton<ref>PMID:28851405</ref>. | ||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
The 3D structure of the complex between FERM domain of the actin-binding moesin and the C-tail domain of cell polarity protein Crumbs shows that the interaction between the 2 proteins involves very few residues<ref>PMID:25792740</ref>. | The 3D structure of the complex between FERM domain of the actin-binding moesin and the C-tail domain of cell polarity protein Crumbs shows that the interaction between the 2 proteins involves <scene name='86/864718/Cv/3'>very few residues</scene><ref>PMID:25792740</ref>. | ||
</StructureSection> | </StructureSection> | ||
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[[3u8z]] - hMO FERM domain 1-296 - human <br /> | [[3u8z]] - hMO FERM domain 1-296 - human <br /> | ||
[[8cit]], [[8ciu]] - hMO FERM domain (mutant) <br /> | |||
[[1ef1]] - hMO FERM domain + C-terminal domain 487-576<br /> | [[1ef1]] - hMO FERM domain + C-terminal domain 487-576<br /> | ||
[[1e5w]] - hMO FERM domain + 1st helix 297-345 <br /> | [[1e5w]] - hMO FERM domain + 1st helix 297-345 <br /> | ||
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[[6txs]] - hMO FERM+helical linker domains + CD44 peptide<br /> | [[6txs]] - hMO FERM+helical linker domains + CD44 peptide<br /> | ||
[[1sgh]] - hMO FERM domain + EBP50 peptide <br /> | [[1sgh]] - hMO FERM domain + EBP50 peptide <br /> | ||
[[8xz5]] - hMO FERM domain + spike protein peptide <br /> | |||
[[8cir]], [[8cis]] - hMO FERM domain + peptide <br /> | |||
[[4yl8]] - MO FERM domain + Crumbs C-terminal peptide - mouse <br /> | |||
[[2i1k]], [[2i1j]] - MO - armyworm <br /> | [[2i1k]], [[2i1j]] - MO - armyworm <br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
