7d8e: Difference between revisions

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'''Unreleased structure'''


The entry 7d8e is ON HOLD  until Paper Publication
==Crystal Structure of double mutant Y115E Y117E human Secretory Glutaminyl Cyclase in complex with LSB-09==
<StructureSection load='7d8e' size='340' side='right'caption='[[7d8e]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7d8e]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D8E FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GYO:~{N}-[(1~{S},2~{S})-2-(2-methoxyphenyl)cyclopropyl]-3~{H}-benzimidazole-5-carboxamide'>GYO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d8e OCA], [https://pdbe.org/7d8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d8e RCSB], [https://www.ebi.ac.uk/pdbsum/7d8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d8e ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/QPCT_HUMAN QPCT_HUMAN] Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.<ref>PMID:15063747</ref> <ref>PMID:18486145</ref> <ref>PMID:21288892</ref>


Authors: Dileep, K.V., Ihara, K., Sakai, N., Shirozu, M., Zhang, K.Y.J.
==See Also==
 
*[[Glutaminyl cyclase|Glutaminyl cyclase]]
Description: Crystal Structure of double mutant Y115E Y117E human Secretory Glutaminyl Cyclase in complex with LSB-09
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Shirozu, M]]
__TOC__
[[Category: Zhang, K.Y.J]]
</StructureSection>
[[Category: Dileep, K.V]]
[[Category: Homo sapiens]]
[[Category: Ihara, K]]
[[Category: Large Structures]]
[[Category: Sakai, N]]
[[Category: Dileep KV]]
[[Category: Ihara K]]
[[Category: Sakai N]]
[[Category: Shirozu M]]
[[Category: Zhang KYJ]]
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