7d5e: Difference between revisions
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New page: '''Unreleased structure''' The entry 7d5e is ON HOLD until Paper Publication Authors: Das, P., Maity, A., Ngo, K.H., Winnerdy, F.R., Bakalar, B., Mechulam, Y., Schmitt, E., Phan, A.T. ... |
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==Left-handed G-quadruplex containing two bulges== | |||
<StructureSection load='7d5e' size='340' side='right'caption='[[7d5e]], [[Resolution|resolution]] 1.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7d5e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D5E FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.296Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d5e OCA], [https://pdbe.org/7d5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d5e RCSB], [https://www.ebi.ac.uk/pdbsum/7d5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d5e ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
G-quadruplex (G4) DNA structures with a left-handed backbone progression have unique and conserved structural features. Studies on sequence dependency of the structures revealed the prerequisites and some minimal motifs required for left-handed G4 formation. To extend the boundaries, we explore the adaptability of left-handed G4s towards the existence of bulges. Here we present two X-ray crystal structures and an NMR solution structure of left-handed G4s accommodating one, two and three bulges. Bulges in left-handed G4s show distinct characteristics as compared to those in right-handed G4s. The elucidation of intricate structural details will help in understanding the possible roles and limitations of these unique structures. | |||
Bulges in left-handed G-quadruplexes.,Das P, Ngo KH, Winnerdy FR, Maity A, Bakalar B, Mechulam Y, Schmitt E, Phan AT Nucleic Acids Res. 2021 Jan 27. pii: 6121459. doi: 10.1093/nar/gkaa1259. PMID:33503265<ref>PMID:33503265</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 7d5e" style="background-color:#fffaf0;"></div> | ||
[[Category: Das | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: | [[Category: Bakalar B]] | ||
[[Category: Das P]] | |||
[[Category: Maity A]] | |||
[[Category: Mechulam Y]] | |||
[[Category: Ngo KH]] | |||
[[Category: Phan AT]] | |||
[[Category: Schmitt E]] | |||
[[Category: Winnerdy FR]] | |||
Latest revision as of 16:27, 29 November 2023
Left-handed G-quadruplex containing two bulges
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