6jvj: Difference between revisions
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==Crystal structure of human MTH1 in complex with compound MI1006== | ==Crystal structure of human MTH1 in complex with compound MI1006== | ||
<StructureSection load='6jvj' size='340' side='right'caption='[[6jvj]]' scene=''> | <StructureSection load='6jvj' size='340' side='right'caption='[[6jvj]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JVJ OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6jvj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JVJ FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.297Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C9L:5-ethyl-N4-methyl-6-piperidin-1-yl-pyrimidine-2,4-diamine'>C9L</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jvj OCA], [https://pdbe.org/6jvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jvj RCSB], [https://www.ebi.ac.uk/pdbsum/6jvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jvj ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref> | |||
==See Also== | |||
*[[7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures|7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cheng YS]] | [[Category: Cheng YS]] | ||
[[Category: Li YH]] | [[Category: Li YH]] | ||
[[Category: Peng C]] | [[Category: Peng C]] | ||
Latest revision as of 10:40, 27 March 2024
Crystal structure of human MTH1 in complex with compound MI1006
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