7kco: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 7kco is ~~ON HOLD until Paper Publication~~

==ROR gamma in complex with SCR2 and compound 3==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[7kco]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KCO OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7KCO FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=WB7:1-[(2-chlorophenyl)methyl]-N-{[4-(methylsulfonyl)phenyl]methyl}-4,5-dihydrospiro[piperidine-4,7-thieno[2,3-c]pyran]-2-carboxamide'>WB7</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7kco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kco OCA], [https://pdbe.org/7kco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kco RCSB], [https://www.ebi.ac.uk/pdbsum/7kco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kco ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Clawson DK]]

[[Category: Durbin JD]]

[[Category: Guo SY]]

[[Category: Stout SL]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7kco is ON HOLD  until Paper Publication
+==ROR gamma in complex with SCR2 and compound 3==
+<StructureSection load='7kco' size='340' side='right'caption='[[7kco]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7kco]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KCO FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=WB7:1-[(2-chlorophenyl)methyl]-N-{[4-(methylsulfonyl)phenyl]methyl}-4,5-dihydrospiro[piperidine-4,7-thieno[2,3-c]pyran]-2-carboxamide'>WB7</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kco OCA], [https://pdbe.org/7kco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kco RCSB], [https://www.ebi.ac.uk/pdbsum/7kco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kco ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Clawson DK]]
+[[Category: Durbin JD]]
+[[Category: Guo SY]]
+[[Category: Stout SL]]