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| The reverse transcription process begins by the telomerase RNA binding to the 3' end of the overhanging DNA sequence. Once primed, the G-rich sequence (~6-8 nucleotides) polymerizes the end of the DNA. The RNA primer then translocates down the new DNA sequence and polymerizes again. This process repeats until the entire telomere is formed. After one side of the telomere is formed, the telomerase attaches the complementary nucleotide bases to complete the double-stranded telomere at the end of the DNA double helix. | | The reverse transcription process begins by the telomerase RNA binding to the 3' end of the overhanging DNA sequence. Once primed, the G-rich sequence (~6-8 nucleotides) polymerizes the end of the DNA. The RNA primer then translocates down the new DNA sequence and polymerizes again. This process repeats until the entire telomere is formed. After one side of the telomere is formed, the telomerase attaches the complementary nucleotide bases to complete the double-stranded telomere at the end of the DNA double helix. |
| | ==Telomerase 3D structures== |
| | [[Telomerase 3D structures]] |
| </StructureSection> | | </StructureSection> |
| ==Telomerase 3D structures==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Telomerase reverse transcriptase
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| **[[5c9h]] – hTERT + RNA - human<br />
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| **[[4mnq]] – hTERT + MHC + b-2-microglobulin + T cell receptor<br />
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| **[[5ugw]] – hTERT thumb domain<br />
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| **[[4lmo]] – TERT RNA binding domain - puffer<br />
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| **[[4o26]] – TERT + telomerase TR – rice fish<br />
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| **[[5cqg]] - rfbTERT + inhibitor - red flour beetle<br />
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| **[[6e53]], [[6uso]], [[6usq]], [[6usp]] - rfbTERT + DNA<br />
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| **[[6usr]] - rfbTERT + DNA + G2P<br />
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| **[[2b2a]] - TtTERT telomerase catalytic subunit (mutant) - ''Tetrahymena thermophila''<br />
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| **[[2r4g]] - TtTERT telomerase catalytic subunit<br />
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| **[[6d6v]] – TtTERT + telomerase-associated protein + TEB2 + RNA + DNA – Cryo EM<br />
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| **[[5c9h]] - TtTERT catalytic subunit + DNA<br />
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| **[[3du6]], [[3du5]] - TcTERT telomerase catalytic subunit - ''Tribolium castaneum''<br />
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| **[[3kyl]] - TcTERT telomerase catalytic subunit + DNA<br />
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| **[[5lgf]] - OgTERT N-terminal - ''Ogataea polymorpha'' - NMR<br />
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| **[[5npt]] – OgTERT N-terminal <br />
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| *Telomerase RNA
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| **[[1q75]], [[2k96]] – hTERC P2b hairpin (mutant) – human – NMR<br />
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| **[[2k95]], [[1na2]] - hTERC P2b hairpin – NMR<br />
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| **[[2l3e]] - hTERC P2a P2b hairpin – NMR<br />
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| **[[2qh2]] - hTERC CR7– NMR<br />
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| **[[1ymo]] - hTERC stem loop IV – NMR<br />
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| **[[1z31]] - hTERC Pj6 hairpin – NMR<br />
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| **[[2kye]] - hTERC P6.1 hairpin – NMR<br />
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| **[[2qh3]], [[2qh4]] - hTERC terminal hairpin loop – NMR<br />
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| **[[5kqe]] - TERC P2b hairpin – ''Oryzias latipes'' - NMR<br />
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| **[[2fey]] - TtTERC P2b hairpin – NMR<br />
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| **[[5kmz]] - TtTERC pseudoknot – NMR<br />
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| **[[2m21]] - TtTERC stem loop IV – NMR<br />
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| **[[2m22]] - TtTERC helix II – NMR<br />
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| **[[2mhi]] - TERC CR4/5 – medaka - NMR<br />
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| **[[2m8k]] - TERC pseudoknot – ''Kluyveromyces lactis'' - NMR<br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
