7kuh: Difference between revisions
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New page: '''Unreleased structure''' The entry 7kuh is ON HOLD Authors: Description: Category: Unreleased Structures |
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The | ==MicroED structure of mVDAC== | ||
<StructureSection load='7kuh' size='340' side='right'caption='[[7kuh]], [[Resolution|resolution]] 3.12Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7kuh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KUH FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron crystallography, [[Resolution|Resolution]] 3.12Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kuh OCA], [https://pdbe.org/7kuh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kuh RCSB], [https://www.ebi.ac.uk/pdbsum/7kuh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kuh ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/VDAC1_MOUSE VDAC1_MOUSE] Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.<ref>PMID:10716730</ref> <ref>PMID:15477379</ref> <ref>PMID:18988731</ref> | |||
==See Also== | |||
*[[Ion channels 3D structures|Ion channels 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Abramson J]] | |||
[[Category: Gonen T]] | |||
[[Category: Hattne J]] | |||
[[Category: Khan F]] | |||
[[Category: Martynowycz MW]] | |||
