2b60: Difference between revisions

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New page: left|200px<br /> <applet load="2b60" size="450" color="white" frame="true" align="right" spinBox="true" caption="2b60, resolution 2.200Å" /> '''Structure of HIV-1...
 
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[[Image:2b60.gif|left|200px]]<br />
<applet load="2b60" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2b60, resolution 2.200&Aring;" />
'''Structure of HIV-1 protease mutant bound to Ritonavir'''<br />


==About this Structure==
==Structure of HIV-1 protease mutant bound to Ritonavir==
2B60 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with RIT and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2B60 OCA].  
<StructureSection load='2b60' size='340' side='right'caption='[[2b60]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2b60]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B60 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=RIT:RITONAVIR'>RIT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b60 OCA], [https://pdbe.org/2b60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b60 RCSB], [https://www.ebi.ac.uk/pdbsum/2b60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b60 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q7SMT3_9HIV1 Q7SMT3_9HIV1]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b6/2b60_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b60 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Agbandje-McKenna, M.]]
[[Category: Agbandje-McKenna M]]
[[Category: Clemente, J.C.]]
[[Category: Clemente JC]]
[[Category: Desai, K.A.]]
[[Category: Desai KA]]
[[Category: Dunn, B.M.]]
[[Category: Dunn BM]]
[[Category: Goodenow, M.M.]]
[[Category: Goodenow MM]]
[[Category: Govindasamy, L.]]
[[Category: Govindasamy L]]
[[Category: Janka, L.K.]]
[[Category: Janka LK]]
[[Category: Jeung, J.A.]]
[[Category: Jeung JA]]
[[Category: McKenna, R.]]
[[Category: McKenna R]]
[[Category: Stow, L.R.]]
[[Category: Stow LR]]
[[Category: GOL]]
[[Category: RIT]]
[[Category: hiv-1 protease]]
[[Category: protease inhibitors]]
[[Category: protein-inhibitor complex]]
[[Category: ritonavir]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov  8 14:43:03 2007''
Retrieved from "https://proteopedia.org/2b60"