1q20: Difference between revisions

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<StructureSection load='1q20' size='340' side='right'caption='[[1q20]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='1q20' size='340' side='right'caption='[[1q20]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1q20]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q20 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Q20 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1q20]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q20 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLO:(3BETA)-3-HYDROXYPREGN-5-EN-20-ONE'>PLO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1q1q|1q1q]], [[1q1z|1q1z]], [[1q22|1q22]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLO:(3BETA)-3-HYDROXYPREGN-5-EN-20-ONE'>PLO</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SULT2B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q20 OCA], [https://pdbe.org/1q20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q20 RCSB], [https://www.ebi.ac.uk/pdbsum/1q20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q20 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1q20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q20 OCA], [http://pdbe.org/1q20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q20 RCSB], [http://www.ebi.ac.uk/pdbsum/1q20 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q20 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ST2B1_HUMAN ST2B1_HUMAN]] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.<ref>PMID:9799594</ref> <ref>PMID:12145317</ref>
[https://www.uniprot.org/uniprot/ST2B1_HUMAN ST2B1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.<ref>PMID:9799594</ref> <ref>PMID:12145317</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Sulfotransferase|Sulfotransferase]]
*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Fuda, H]]
[[Category: Fuda H]]
[[Category: Lee, K A]]
[[Category: Lee KA]]
[[Category: Lee, Y C]]
[[Category: Lee YC]]
[[Category: Negishi, M]]
[[Category: Negishi M]]
[[Category: Pedersen, L C]]
[[Category: Pedersen LC]]
[[Category: Strott, C A]]
[[Category: Strott CA]]
[[Category: Cholesterol]]
[[Category: Pap]]
[[Category: Pregnenolone]]
[[Category: Sulfotransferase]]
[[Category: Sult2b1b]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/1q20"