7dn3: Difference between revisions

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'''Unreleased structure'''


The entry 7dn3 is ON HOLD
==Structure of Human RNA Polymerase III elongation complex==
<StructureSection load='7dn3' size='340' side='right'caption='[[7dn3]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7dn3]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DN3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DN3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dn3 OCA], [https://pdbe.org/7dn3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dn3 RCSB], [https://www.ebi.ac.uk/pdbsum/7dn3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dn3 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/RPAC1_HUMAN RPAC1_HUMAN] Hypomyelination-hypogonadotropic hypogonadism-hypodontia syndrome;Treacher-Collins syndrome. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/RPAC1_HUMAN RPAC1_HUMAN] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively. POLR1C/RPAC1 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft.[UniProtKB:P07703]<ref>PMID:20413673</ref> <ref>PMID:34671025</ref> <ref>PMID:34887565</ref> <ref>PMID:36271492</ref> <ref>PMID:26151409</ref>


Authors: Li, L., Yu, Z., Zhao, D., Ren, Y., Hou, H., Xu, Y.
==See Also==
 
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
Description: Structure of Human RNA Polymerase III elongation complex
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Li, L]]
__TOC__
[[Category: Hou, H]]
</StructureSection>
[[Category: Ren, Y]]
[[Category: Homo sapiens]]
[[Category: Yu, Z]]
[[Category: Large Structures]]
[[Category: Xu, Y]]
[[Category: Hou H]]
[[Category: Zhao, D]]
[[Category: Li L]]
[[Category: Ren Y]]
[[Category: Xu Y]]
[[Category: Yu Z]]
[[Category: Zhao D]]
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