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==BRD4-BD1 bound with compound 40==
==BRD4-BD1 bound with compound 40==
<StructureSection load='6lim' size='340' side='right'caption='[[6lim]]' scene=''>
<StructureSection load='6lim' size='340' side='right'caption='[[6lim]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LIM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LIM FirstGlance]. <br>
<table><tr><td colspan='2'>[[6lim]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LIM FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lim OCA], [http://pdbe.org/6lim PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lim RCSB], [http://www.ebi.ac.uk/pdbsum/6lim PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lim ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7590951&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EE9:(3~{R})-6-[(4-isoquinolin-4-ylpyrimidin-2-yl)amino]-1,3-dimethyl-4-propan-2-yl-3~{H}-quinoxalin-2-one'>EE9</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lim OCA], [https://pdbe.org/6lim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lim RCSB], [https://www.ebi.ac.uk/pdbsum/6lim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lim ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
==See Also==
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cao D]]
[[Category: Cao D]]
[[Category: Li Y]]
[[Category: Li Y]]
[[Category: Xiong B]]
[[Category: Xiong B]]
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