7b9t: Difference between revisions
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New page: '''Unreleased structure''' The entry 7b9t is ON HOLD Authors: Sijbesma, E., Ottmann, C. Description: Cys-45-tethered stabilizer 5 of 14-3-3(sigma)/ERa PPI [[Category: Unreleased Struct... |
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The | ==Cys-45-tethered stabilizer 5 of 14-3-3(sigma)/ERa PPI== | ||
<StructureSection load='7b9t' size='340' side='right'caption='[[7b9t]], [[Resolution|resolution]] 1.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7b9t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B9T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B9T FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=T4Z:2-(4-chlorophenyl)sulfanyl-~{N}-(3-sulfanylpropyl)ethanamide'>T4Z</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b9t OCA], [https://pdbe.org/7b9t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b9t RCSB], [https://www.ebi.ac.uk/pdbsum/7b9t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b9t ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The systematic discovery of functional fragments binding to the composite interface of protein complexes is a first critical step for the development of orthosteric stabilizers of protein-protein interactions (PPIs). We have previously shown that disulfide trapping successfully yielded covalent stabilizers for the PPI of 14-3-3 with the estrogen receptor ERalpha. Here we provide an assessment of the composite PPI target pocket and the molecular characteristics of various fragments binding to a specific subpocket. Evaluating structure-activity relationships highlights the basic principles for PPI stabilization by these covalent fragments that engage a relatively large and exposed binding pocket at the protein/peptide interface with a "molecular glue" mode of action. | |||
Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers.,Sijbesma E, Hallenbeck KK, Andrei SA, Rust RR, Adriaans JMC, Brunsveld L, Arkin MR, Ottmann C ACS Med Chem Lett. 2021 May 10;12(6):976-982. doi: , 10.1021/acsmedchemlett.1c00088. eCollection 2021 Jun 10. PMID:34136078<ref>PMID:34136078</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Ottmann | <div class="pdbe-citations 7b9t" style="background-color:#fffaf0;"></div> | ||
[[Category: Sijbesma | |||
==See Also== | |||
*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ottmann C]] | |||
[[Category: Sijbesma E]] | |||
Latest revision as of 09:20, 9 October 2024
Cys-45-tethered stabilizer 5 of 14-3-3(sigma)/ERa PPI
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