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==Structure of the N-terminal RNA-binding Domain of the SARS CoV Nucleocapsid Protein==
==Structure of the N-terminal RNA-binding Domain of the SARS CoV Nucleocapsid Protein==
<StructureSection load='1ssk' size='340' side='right'caption='[[1ssk]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='1ssk' size='340' side='right'caption='[[1ssk]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ssk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cvhsa Cvhsa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1SSK FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ssk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome-related_coronavirus Severe acute respiratory syndrome-related coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SSK FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">N ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 CVHSA])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1ssk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ssk OCA], [http://pdbe.org/1ssk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ssk RCSB], [http://www.ebi.ac.uk/pdbsum/1ssk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ssk ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ssk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ssk OCA], [https://pdbe.org/1ssk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ssk RCSB], [https://www.ebi.ac.uk/pdbsum/1ssk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ssk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NCAP_CVHSA NCAP_CVHSA]] Major structural component of virions that associates with genomic RNA to form a long, flexible, helical nucleocapsid (By similarity).  
[https://www.uniprot.org/uniprot/NCAP_SARS NCAP_SARS] Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (PubMed:17210170). May modulate transforming growth factor-beta signaling by binding host SMAD3 (PubMed:18055455).[HAMAP-Rule:MF_04096]<ref>PMID:17210170</ref> <ref>PMID:18055455</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cvhsa]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Fesik, S W]]
[[Category: Severe acute respiratory syndrome-related coronavirus]]
[[Category: Gunasekera, A]]
[[Category: Fesik SW]]
[[Category: Hajduk, P]]
[[Category: Gunasekera A]]
[[Category: Huang, Q]]
[[Category: Hajduk P]]
[[Category: Liu, Z]]
[[Category: Huang Q]]
[[Category: Mack, J]]
[[Category: Liu Z]]
[[Category: Olejniczak, E T]]
[[Category: Mack J]]
[[Category: Petros, A M]]
[[Category: Olejniczak ET]]
[[Category: Xu, N]]
[[Category: Petros AM]]
[[Category: Yu, L]]
[[Category: Xu N]]
[[Category: Nucleocapsid protein]]
[[Category: Yu L]]
[[Category: Structural protein]]
Retrieved from "https://proteopedia.org/1ssk"