7beq: Difference between revisions
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New page: '''Unreleased structure''' The entry 7beq is ON HOLD Authors: Description: Category: Unreleased Structures |
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==MicroED structure of the MyD88 TIR domain higher-order assembly== | |||
<StructureSection load='7beq' size='340' side='right'caption='[[7beq]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7beq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BEQ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron crystallography, [[Resolution|Resolution]] 3Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7beq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7beq OCA], [https://pdbe.org/7beq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7beq RCSB], [https://www.ebi.ac.uk/pdbsum/7beq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7beq ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN] Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:[https://omim.org/entry/612260 612260]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.<ref>PMID:19506249</ref> <ref>PMID:18669862</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN] Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity).<ref>PMID:9013863</ref> <ref>PMID:15361868</ref> <ref>PMID:18292575</ref> <ref>PMID:19506249</ref> | |||
==See Also== | |||
*[[TIR domain-containing adapter protein|TIR domain-containing adapter protein]] | |||
== References == | |||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Abbey B]] | |||
[[Category: Aquila A]] | |||
[[Category: Clabbers MTB]] | |||
[[Category: Croll TI]] | |||
[[Category: Darmanin C]] | |||
[[Category: Gambin Y]] | |||
[[Category: Holmes S]] | |||
[[Category: Hunter DJB]] | |||
[[Category: Hunter MS]] | |||
[[Category: Kobe B]] | |||
[[Category: Liang M]] | |||
[[Category: Malde AK]] | |||
[[Category: Muusse TW]] | |||
[[Category: Nanson JD]] | |||
[[Category: Rahaman MH]] | |||
[[Category: Sierecki E]] | |||
[[Category: Thygesen SJ]] | |||
[[Category: Vajjhala P]] | |||
[[Category: Ve T]] | |||
[[Category: Xu H]] | |||
[[Category: Yoon CH]] | |||
[[Category: Zatsepin NA]] | |||
[[Category: Zhao J]] | |||
