7dqt: Difference between revisions
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New page: '''Unreleased structure''' The entry 7dqt is ON HOLD Authors: Kikuchi, M., Iizuka, Y., Yamauchi, T., Tsunoda, M. Description: Crystal structure of O6-methylguanine methyltransferase Y9... |
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==Crystal structure of O6-methylguanine methyltransferase Y91F variant== | |||
<StructureSection load='7dqt' size='340' side='right'caption='[[7dqt]], [[Resolution|resolution]] 1.13Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7dqt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii_str._7 Sulfurisphaera tokodaii str. 7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DQT FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.13Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dqt OCA], [https://pdbe.org/7dqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dqt RCSB], [https://www.ebi.ac.uk/pdbsum/7dqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dqt ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/OGT_SULTO OGT_SULTO] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity). | |||
==See Also== | |||
*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Kikuchi | [[Category: Sulfurisphaera tokodaii str. 7]] | ||
[[Category: Tsunoda | [[Category: Iizuka Y]] | ||
[[Category: | [[Category: Kikuchi M]] | ||
[[Category: Tsunoda M]] | |||
[[Category: Yamauchi T]] | |||
Latest revision as of 16:38, 29 November 2023
Crystal structure of O6-methylguanine methyltransferase Y91F variant
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