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==NMR structure of transmembrane segment IV of the NHE1 isoform of the Na+/H+ exchanger==
==NMR structure of transmembrane segment IV of the NHE1 isoform of the Na+/H+ exchanger==
<StructureSection load='1y4e' size='340' side='right'caption='[[1y4e]], [[NMR_Ensembles_of_Models | 100 NMR models]]' scene=''>
<StructureSection load='1y4e' size='340' side='right'caption='[[1y4e]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1y4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y4E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Y4E FirstGlance]. <br>
<table><tr><td colspan='2'>[[1y4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y4E FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HSL:HOMOSERINE+LACTONE'>HSL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SLC9A1, APNH1, NHE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HSL:HOMOSERINE+LACTONE'>HSL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1y4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y4e OCA], [http://pdbe.org/1y4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y4e RCSB], [http://www.ebi.ac.uk/pdbsum/1y4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y4e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y4e OCA], [https://pdbe.org/1y4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y4e RCSB], [https://www.ebi.ac.uk/pdbsum/1y4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y4e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SL9A1_HUMAN SL9A1_HUMAN]] Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.<ref>PMID:8901634</ref> <ref>PMID:11350981</ref> <ref>PMID:15035633</ref>
[https://www.uniprot.org/uniprot/SL9A1_HUMAN SL9A1_HUMAN] Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.<ref>PMID:8901634</ref> <ref>PMID:11350981</ref> <ref>PMID:15035633</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Fliegel, L]]
[[Category: Fliegel L]]
[[Category: Li, X]]
[[Category: Li X]]
[[Category: Lindhout, D A]]
[[Category: Lindhout DA]]
[[Category: Liu, Y]]
[[Category: Liu Y]]
[[Category: Rainey, J K]]
[[Category: Rainey JK]]
[[Category: Slepkov, E R]]
[[Category: Slepkov ER]]
[[Category: Sykes, B D]]
[[Category: Sykes BD]]
[[Category: Membrane protein]]
[[Category: Nhe1 isoform]]
[[Category: Transmembrane]]
Retrieved from "https://proteopedia.org/1y4e"