7bml: Difference between revisions
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New page: '''Unreleased structure''' The entry 7bml is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Crystal structure of outer surface protein C (OspC) from Borrelia burgdorferi== | |||
<StructureSection load='7bml' size='340' side='right'caption='[[7bml]], [[Resolution|resolution]] 1.85Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7bml]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi Borreliella burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BML FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bml OCA], [https://pdbe.org/7bml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bml RCSB], [https://www.ebi.ac.uk/pdbsum/7bml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bml ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/OSPC2_BORBG OSPC2_BORBG] Major immunodominant protein in mammalian hosts. Required for initial stages of mammalian infection. Inhibits macrophage-mediated phagocytosis of the bacteria. Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue. Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo.[UniProtKB:Q07337] | |||
==See Also== | |||
*[[Outer surface protein|Outer surface protein]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Borreliella burgdorferi]] | |||
[[Category: Large Structures]] | |||
[[Category: Bierwagen P]] | |||
[[Category: Jaskolski M]] | |||
[[Category: Ruszkowski M]] | |||
[[Category: Sliwiak J]] | |||
[[Category: Urbanowicz A]] | |||
Latest revision as of 12:31, 1 February 2024
Crystal structure of outer surface protein C (OspC) from Borrelia burgdorferi
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