Replication protein E1: Difference between revisions

(2 intermediate revisions by one other user not shown)

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==Function==

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== Structural highlights ==

The complex between BPV1 DBD and 21-bp DNA (PDB code [[1ksx]]) shows 2 DBD-DNA binding modules: a binding loop and a binding helix each interacting with a single strand. The protein-DNA interactions are hydrophilic to phosphate atoms and van der Waals hydrophobic ones<ref>PMID:11889054</ref>.

The complex between BPV1 DBD and 21-bp DNA (PDB code [[1ksx]]) shows 2 DBD-DNA binding modules: a <scene name='87/873777/Cv/2'>binding loop</scene> and a <scene name='87/873777/Cv/4'>binding helix</scene> each interacting with a single strand. The protein-DNA interactions are hydrophilic to phosphate atoms and van der Waals hydrophobic ones<ref>PMID:11889054</ref>.

</StructureSection>

==3D structures of replication protein E1==

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Domains: helicase 301-605; DNA-binding (DBD) 286-365

[[1r9w]] - ~~RPE1~~ DBD ~~- HPV18~~

[[1r9w]] - HpvRPE1 DBD – Human papilloma virus 18

[[1tue]] - ~~RPE1~~ 428-631 (mutant) + RPE2 TAD

[[1tue]] - HpvRPE1 428-631 (mutant) + RPE2 TAD

[[~~2v9p~~]] - ~~RPE1~~ helicase domain ~~- BPV1~~

[[2gxa]] - DpvRPE1 helicase domain + DNA + ADP – Delta papilloma virus 4

[[5a9k]] - ~~RPE1~~ helicase domain - Cryo EM

[[5a9k]] - BpvRPE1 helicase domain – Bovine papilloma virus - Cryo EM

[[~~2gxa~~]] - ~~RPE1~~ helicase domain ~~+ DNA + ADP~~

[[2v9p]] - BpvRPE1 helicase domain

[[1f08]] - ~~RPE1~~ DBD

[[1f08]] - BpvRPE1 DBD

[[1ksx]], [[1ksy]] - ~~RPE1~~ DBD + DNA

[[1ksx]], [[1ksy]] - BpvRPE1 DBD + DNA

[[7apd]] - BpvRPE1 helicase domain + DNA – Cryo EM

== References ==

[[Category:Topic Page]]

Replication protein E1: Difference between revisions

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@@ Line 1: / Line 1: @@
-<StructureSection load='1ksx' size='340' side='right' caption='Bovine papillomavirus 1 replication protein E1 complex with DNA (PDB code [[1ksx]])' scene=''>
+<StructureSection load='1ksx' size='340' side='right' caption='Bovine papillomavirus 1 replication protein E1 complex with DNA (PDB code [[1ksx]])' scene='87/873777/Cv/1'>
 ==Function==
@@ Line 15: / Line 15: @@
 == Structural highlights ==
-The complex between BPV1 DBD and 21-bp DNA (PDB code [[1ksx]]) shows 2 DBD-DNA binding modules: a binding loop and a binding helix each interacting with a single strand. The protein-DNA interactions are hydrophilic to phosphate atoms and van der Waals hydrophobic ones<ref>PMID:11889054</ref>.
+The complex between BPV1 DBD and 21-bp DNA (PDB code [[1ksx]]) shows 2 DBD-DNA binding modules: a <scene name='87/873777/Cv/2'>binding loop</scene> and a <scene name='87/873777/Cv/4'>binding helix</scene> each interacting with a single strand. The protein-DNA interactions are hydrophilic to phosphate atoms and van der Waals hydrophobic ones<ref>PMID:11889054</ref>.
 </StructureSection>
 ==3D structures of replication protein E1==
@@ Line 23: / Line 23: @@
 Domains: helicase 301-605; DNA-binding (DBD) 286-365
-[[1r9w]] - RPE1 DBD - HPV18<br />
+[[1r9w]] - HpvRPE1 DBD – Human papilloma virus 18<br />
-[[1tue]] - RPE1 428-631 (mutant) + RPE2 TAD<br />
+[[1tue]] - HpvRPE1 428-631 (mutant) + RPE2 TAD<br />
-[[2v9p]] - RPE1 helicase domain - BPV1<br />
+[[2gxa]] - DpvRPE1 helicase domain + DNA + ADP – Delta papilloma virus 4<br />
-[[5a9k]] - RPE1 helicase domain - Cryo EM<br />
+[[5a9k]] - BpvRPE1 helicase domain – Bovine papilloma virus - Cryo EM<br />
-[[2gxa]] - RPE1 helicase domain + DNA + ADP<br />
+[[2v9p]] - BpvRPE1 helicase domain <br />
-[[1f08]] - RPE1 DBD<br />
+[[1f08]] - BpvRPE1 DBD<br />
-[[1ksx]], [[1ksy]] - RPE1 DBD + DNA<br />
+[[1ksx]], [[1ksy]] - BpvRPE1 DBD + DNA<br />
+[[7apd]] - BpvRPE1 helicase domain + DNA – Cryo EM<br />
 == References ==
 <references/>
 [[Category:Topic Page]]