Chalcone synthase: Difference between revisions

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==Function==

'''Chalcone synthase''' is ~~part of~~ the ~~tripartite ATP-dependent transporters which consist~~ of ~~three protiens: DctP, DctM~~ and ~~DctQ~~. ~~DctP is a periplasmic C4~~-~~dicarboxylate~~-~~binding receptor~~<ref>PMID:~~10627041~~</ref>.

'''Chalcone synthase''' (CHS) is essential for the biosynthesis of flavonoids and anthocyanin pigments in plants. CHS condenses p-coumaroyl-CoA and three malonyl-CoA to produce the polyketide naringenin

<ref>PMID:25404490</ref>.

== ~~Disease~~ ==

==Relevance==

~~==Relevance==~~

The CHS biosynthesis product naringenin has inhibitory activity on a Cyt P450 isoform which can have carcinogenic effect <ref>PMID:15744083</ref> and has significant antioxidant properties.

== Structural highlights ==

</StructureSection>

<scene name='87/873790/Cv/3'>CoA binding site</scene>. The Cys residue (3-sulfinoalanine is shown in this case) is the catalytic nucleophile tethering the starting group and the growing polyketide chain<ref>PMID:10653632</ref>. Water molecules are shown as red spheres.

==~~Chalcone~~ synthase==

</StructureSection>

==3D structures of chalcone synthase==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

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*Chalcone synthase

**[[1bi5]], [[1u0v]] - ~~alCS~~ 2 - alfalfa

**[[1bi5]], [[1u0v]] - alCHS 2 - alfalfa

**[1d6f]], [[1d6i]], [[1i86]], [[1i88]], [[1i89]], [[1i8b]], [[1jwx]] - ~~alCS~~ 2 (mutant)

**[[1d6f]], [[1d6i]], [[1i86]], [[1i88]], [[1i89]], [[1i8b]], [[1jwx]] - alCHS 2 (mutant)

**[[6dxb]] - ~~AtCS~~ - ''Arabidopsis thaliana''

**[[6dxb]] - AtCHS - ''Arabidopsis thaliana''

**[[6dxd]], [[6dxe]] - ~~AtCS~~ (mutant)

**[[6dxd]], [[6dxe]] - AtCHS (mutant)

**[[4wum]] - CS - freesia

**[[4wum]] - CHS - freesia

**[[6dxa]] - CS - pine

**[[6dxa]] - CHS - pine

**[[6dx9]] - CS - horsetail

**[[6dx9]] - CHS - horsetail

**[[7bus]] - CS - soybean

**[[7bus]] - sbCHS - soybean

**[[~~7dx7~~]] - CS - moss

**[[6dx7]] - CHS - moss

**[[5uc5]] - CHS - apple

**[[4yjy]] - CHS 1 - rice

**[[8v8n]] - swCHS (mutant) - switchgrass

**[[6dx8]], [[6dxc]], [[6dxf]] - CHS - ''Selaginella moellendorffii''

**[[6cqb]] - CHS - kava

**[[7yj5]] - ScCHS 1 – ''Stenoloma chusanum''

**[[7vey]] - CpCHS 1 – ''Cyclosorus parasiticus''

*Chalcone synthase complex

**[[1cgk]] - ~~alCS~~ + naringenin

**[[1cgk]] - alCHS + naringenin

**[[1cgz]] - ~~alCS~~ + resveratol

**[[1cgz]] - alCHS + resveratol

**[[1u0w]] - ~~alCS~~ 2 (mutant) + resveratol

**[[1u0w]] - alCHS 2 (mutant) + resveratol

**[[1bq6]] - ~~alCS~~ + CoA

**[[1bq6]] - alCHS + CoA

**[[1cml]] - ~~alCS~~ + malonyl-CoA

**[[1d6h]] - alCHS (mutant) + CoA

**[[1chw]] - ~~alCS~~ (mutant) + hexanoyl-CoA

**[[1cml]] - alCHS + malonyl-CoA

**[[1chw]] - alCHS (mutant) + hexanoyl-CoA

**[[7bur]] - sbCHS + naringenin

**[[8jrd]] - sbCHS + naringenin + CoA

**[[8v8m]] - swCHS + naringenin + CoA

**[[7yj8]] - ScCHS + pinocembrin

**[[7yja]] - ScCHS + pinocembrin + CoA

**[[7yj7]] - ScCHS + naringenin

**[[7yj6]] - ScCHS + CoA

**[[7yj9]] - ScCHS + naringenin + CoA

**[[7yjb]] - ScCHS + eriodictyol + CoA

**[[7vez]] - CpCHS 1 + naringenin

**[[7vf0]] - CpCHS 1 + naringenin + CoA

**[[7f08]] - CHS + CoA – ''Abrus precatorius''

**[[8b32]] - HvCHS + CoA – ''Hordeum vulgare''

**[[8b3c]] - HvCHS + CoA + eriodictyol

**[[8b35]] - HvCHS + naringenin + CoA

}}

== References ==

[[Category:Topic Page]]

@@ Line 1: / Line 1: @@
-<StructureSection load='4mhf' size='340' side='right' caption='DctP complex with glucuronate (PDB code [[4mhf]])' scene=''>
+<StructureSection load='1d6h' size='340' side='right' caption='Alfalfa chalcone synthase containing sulfinoalanine complex with CoA and sulfate  (PDB code [[1d6h]])' scene='87/873790/Cv/1'>
 ==Function==
-'''Chalcone synthase''' is part of the tripartite ATP-dependent transporters which consist of three protiens: DctP, DctM and DctQ.  DctP is a periplasmic C4-dicarboxylate-binding receptor<ref>PMID:10627041</ref>.
+'''Chalcone synthase''' (CHS) is essential for the biosynthesis of flavonoids and anthocyanin pigments in plants. CHS condenses p-coumaroyl-CoA and three malonyl-CoA to produce the polyketide naringenin
+<ref>PMID:25404490</ref>.
-== Disease ==
+==Relevance==
-==Relevance==
+The CHS biosynthesis product naringenin has inhibitory activity on a Cyt P450 isoform which can have carcinogenic effect <ref>PMID:15744083</ref> and has significant antioxidant properties.
 == Structural highlights ==
-</StructureSection>
+<scene name='87/873790/Cv/3'>CoA binding site</scene>. The Cys residue (3-sulfinoalanine is shown in this case) is the catalytic nucleophile tethering the starting group and the growing polyketide chain<ref>PMID:10653632</ref>. Water molecules are shown as red spheres.
-==Chalcone synthase==
+</StructureSection>
+==3D structures of chalcone synthase==
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
@@ Line 19: / Line 21: @@
 *Chalcone synthase
-**[[1bi5]], [[1u0v]] - alCS 2 - alfalfa<br />
+**[[1bi5]], [[1u0v]] - alCHS 2 - alfalfa<br />
-**[1d6f]], [[1d6i]], [[1i86]], [[1i88]], [[1i89]], [[1i8b]], [[1jwx]] - alCS 2 (mutant)<br />
+**[[1d6f]], [[1d6i]], [[1i86]], [[1i88]], [[1i89]], [[1i8b]], [[1jwx]] - alCHS 2 (mutant)<br />
-**[[6dxb]] - AtCS  - ''Arabidopsis thaliana''<br />
+**[[6dxb]] - AtCHS  - ''Arabidopsis thaliana''<br />
-**[[6dxd]], [[6dxe]] - AtCS (mutant) <br />
+**[[6dxd]], [[6dxe]] - AtCHS (mutant) <br />
-**[[4wum]] - CS - freesia<br />
+**[[4wum]] - CHS - freesia<br />
-**[[6dxa]] - CS - pine<br />
+**[[6dxa]] - CHS - pine<br />
-**[[6dx9]] - CS - horsetail<br />
+**[[6dx9]] - CHS - horsetail<br />
-**[[7bus]] - CS - soybean<br />
+**[[7bus]] - sbCHS - soybean<br />
-**[[7dx7]] - CS - moss<br />
+**[[6dx7]] - CHS - moss<br />
+**[[5uc5]] - CHS - apple<br />
+**[[4yjy]] - CHS 1 - rice<br />
+**[[8v8n]] - swCHS (mutant) - switchgrass<br />
+**[[6dx8]], [[6dxc]], [[6dxf]] - CHS - ''Selaginella moellendorffii''<br />
+**[[6cqb]] - CHS - kava<br />
+**[[7yj5]] - ScCHS 1 – ''Stenoloma chusanum''<br />
+**[[7vey]] - CpCHS 1 – ''Cyclosorus parasiticus''<br />
 *Chalcone synthase complex
-**[[1cgk]] - alCS + naringenin<br />
+**[[1cgk]] - alCHS + naringenin<br />
-**[[1cgz]] - alCS + resveratol<br />
+**[[1cgz]] - alCHS + resveratol<br />
-**[[1u0w]] - alCS 2 (mutant) + resveratol<br />
+**[[1u0w]] - alCHS 2 (mutant) + resveratol<br />
-**[[1bq6]] - alCS + CoA<br />
+**[[1bq6]] - alCHS + CoA<br />
-**[[1cml]] - alCS + malonyl-CoA<br />
+**[[1d6h]] - alCHS (mutant) + CoA<br />
-**[[1chw]] - alCS (mutant) + hexanoyl-CoA<br />
+**[[1cml]] - alCHS + malonyl-CoA<br />
+**[[1chw]] - alCHS (mutant) + hexanoyl-CoA<br />
+**[[7bur]] - sbCHS + naringenin<br />
+**[[8jrd]] - sbCHS + naringenin + CoA<br />
+**[[8v8m]] - swCHS + naringenin + CoA<br />
+**[[7yj8]] - ScCHS + pinocembrin<br />
+**[[7yja]] - ScCHS + pinocembrin + CoA<br />
+**[[7yj7]] - ScCHS + naringenin<br />
+**[[7yj6]] - ScCHS + CoA<br />
+**[[7yj9]] - ScCHS + naringenin + CoA<br />
+**[[7yjb]] - ScCHS + eriodictyol + CoA<br />
+**[[7vez]] - CpCHS 1 + naringenin <br />
+**[[7vf0]] - CpCHS 1 + naringenin + CoA <br />
+**[[7f08]] - CHS + CoA – ''Abrus precatorius''<br />
+**[[8b32]] - HvCHS + CoA – ''Hordeum vulgare''<br />
+**[[8b3c]] - HvCHS + CoA + eriodictyol <br />
+**[[8b35]] - HvCHS + naringenin + CoA <br />
+}}
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]

Chalcone synthase: Difference between revisions

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