7dyv: Difference between revisions
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New page: '''Unreleased structure''' The entry 7dyv is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Human JMJD5 in complex with MN and 5-(benzylamino)pyridine-2,4-dicarboxylic acid.== | |||
<StructureSection load='7dyv' size='340' side='right'caption='[[7dyv]], [[Resolution|resolution]] 1.92Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7dyv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DYV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DYV FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HRF:5-(benzylamino)pyridine-2,4-dicarboxylic+acid'>HRF</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dyv OCA], [https://pdbe.org/7dyv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dyv RCSB], [https://www.ebi.ac.uk/pdbsum/7dyv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dyv ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Brewitz L]] | |||
[[Category: Nakashima Y]] | |||
[[Category: Schofield CJ]] | |||
Latest revision as of 10:09, 16 August 2023
Human JMJD5 in complex with MN and 5-(benzylamino)pyridine-2,4-dicarboxylic acid.
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