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==Solution structure of the CH domain from human MICAL-3 protein==
==Solution structure of the CH domain from human MICAL-3 protein==
<StructureSection load='2d88' size='340' side='right'caption='[[2d88]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2d88' size='340' side='right'caption='[[2d88]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2d88]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D88 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2d88]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D88 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MICAL3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d88 OCA], [https://pdbe.org/2d88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d88 RCSB], [https://www.ebi.ac.uk/pdbsum/2d88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d88 ProSAT], [https://www.topsan.org/Proteins/RSGI/2d88 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d88 OCA], [https://pdbe.org/2d88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d88 RCSB], [https://www.ebi.ac.uk/pdbsum/2d88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d88 ProSAT], [https://www.topsan.org/Proteins/RSGI/2d88 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/MICA3_HUMAN MICA3_HUMAN]] Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity). Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process.<ref>PMID:21596566</ref>
[https://www.uniprot.org/uniprot/MICA3_HUMAN MICA3_HUMAN] Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity). Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process.<ref>PMID:21596566</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Inoue, M]]
[[Category: Inoue M]]
[[Category: Kigawa, T]]
[[Category: Kigawa T]]
[[Category: Koshiba, S]]
[[Category: Koshiba S]]
[[Category: Structural genomic]]
[[Category: Tomizawa T]]
[[Category: Tomizawa, T]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: All alpha]]
[[Category: Calponin homology domain]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Protein binding]]
[[Category: Rsgi]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/2d88"