2d9n: Difference between revisions
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==Solution structure of CCCH type zinc-finger domain 2 in Cleavage and polyadenylation specificity factor== | ==Solution structure of CCCH type zinc-finger domain 2 in Cleavage and polyadenylation specificity factor== | ||
<StructureSection load='2d9n' size='340' side='right'caption='[[2d9n | <StructureSection load='2d9n' size='340' side='right'caption='[[2d9n]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2d9n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2d9n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D9N FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d9n OCA], [https://pdbe.org/2d9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d9n RCSB], [https://www.ebi.ac.uk/pdbsum/2d9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d9n ProSAT], [https://www.topsan.org/Proteins/RSGI/2d9n TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d9n OCA], [https://pdbe.org/2d9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d9n RCSB], [https://www.ebi.ac.uk/pdbsum/2d9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d9n ProSAT], [https://www.topsan.org/Proteins/RSGI/2d9n TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CPSF4_HUMAN CPSF4_HUMAN] Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).<ref>PMID:9224719</ref> <ref>PMID:14749727</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Abe | [[Category: Abe C]] | ||
[[Category: Inoue | [[Category: Inoue M]] | ||
[[Category: Kigawa | [[Category: Kigawa T]] | ||
[[Category: Muto | [[Category: Muto Y]] | ||
[[Category: Shirouzu M]] | |||
[[Category: Shirouzu | [[Category: Terada T]] | ||
[[Category: Terada | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | |||
Latest revision as of 11:36, 22 May 2024
Solution structure of CCCH type zinc-finger domain 2 in Cleavage and polyadenylation specificity factor
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