Ubiquitin-fold modifier: Difference between revisions

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__TOC__

== Function ==

'''Ubiquitin-fold modifier''' (Ufm1) is a member of the ubiquitin-like family. Ufm1 is covalently attached to Lys residues of substrate proteins<ref>PMID:21494687</ref>. This attachment is called Ufmylation and requires '''Ubiquitin-like modifier activating enzyme''' (~~UBA5~~) and '''Ufm1-conjugating enzyme''' (Ufc1). Ufmylation is a type of post-translational modification that deals with fine-tuned and complex cellular activities and is involved in reticulophagy induced by ER stress<ref>PMID:31129212</ref>. Ufmylation is aribosomal modification specialized to facilitate metazoan-specific protein biogenesis at the ER<ref>PMID:30626644</ref>.

'''Ubiquitin-fold modifier''' (Ufm1) is a member of the ubiquitin-like family. Ufm1 is covalently attached to Lys residues of substrate proteins<ref>PMID:21494687</ref>. This attachment is called Ufmylation and requires '''Ubiquitin-like modifier activating enzyme''' (Uba5) and '''Ufm1-conjugating enzyme''' (Ufc1). Ufmylation is a type of post-translational modification that deals with fine-tuned and complex cellular activities and is involved in reticulophagy induced by ER stress<ref>PMID:31129212</ref>. Ufmylation is aribosomal modification specialized to facilitate metazoan-specific protein biogenesis at the ER<ref>PMID:30626644</ref>.

== Relevance ==

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<scene name='87/873802/Cv/2'>The 3D structure of the complex between Ufm1 and UBA</scene> shows the Ufm1 critical binding sequence and the <scene name='87/873802/Cv/4'>interactions between the 2 modifying enzymes</scene> <ref>PMID:27653677</ref>.

~~</StructureSection>~~

== 3D Structures of Ubiquitin-fold modifier ==

~~Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}~~

[[Ubiquitin-fold modifier 3D structures]]

~~{{#tree:id=OrganizedByTopic|openlevels=0|~~

*Ubiquitin-fold modifier

**[[5ia7]] – hUfm1 - human

**[[1wxs]] – hUfm1 - NMR

**[[5hkh]] – hUfm1 + peptide

**[[5iaa]] – hUfm1 + UBA5

**[[5l95]] – hUfm1 + UBA5 + AMP

**[[6h77]] – hUfm1 + UBA5 + ATP

**[[5xda]] – Ufm1 + Umf1-specific protease - ''Caenorhabditis elegans''

**[[6izg]] ~~– Ufm1 - ''Trypanosoma brucei'' - NMR ~~

*Umf1-conjugating enzyme

**[[2z6o]], [[2z6p]], [[3evx]] – hUfc1

**[[2k07]] – hUfc1 - NMR

*Ubiquitin-like modifier activating enzyme

**[[3h8v]], [[6h78]] – hUBA5 + ATP

**[[3guc]] – hUBA5 + AMPPNP

}}

==References==

</StructureSection>

[[Category:Topic Page]]

Ubiquitin-fold modifier: Difference between revisions

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@@ Line 1: / Line 1: @@
 <StructureSection load='5iaa' size='340' side='right' caption='Human ubiquitin-fold modifier (pink, yellow) complex with ubiquitin-like modifier activating enzyme (green, cyan) (PDB code [[5iaa]]' scene='87/873802/Cv/1' >
+__TOC__
 == Function ==
-'''Ubiquitin-fold modifier''' (Ufm1) is a member of the ubiquitin-like family.  Ufm1 is covalently attached to Lys residues of substrate proteins<ref>PMID:21494687</ref>.  This attachment is called Ufmylation and requires  '''Ubiquitin-like modifier activating enzyme''' (UBA5) and '''Ufm1-conjugating enzyme''' (Ufc1).  Ufmylation is a type of post-translational modification that deals with fine-tuned and complex cellular activities and is involved in reticulophagy induced by ER stress<ref>PMID:31129212</ref>.  Ufmylation is aribosomal modification specialized to facilitate metazoan-specific protein biogenesis at the ER<ref>PMID:30626644</ref>.
+'''Ubiquitin-fold modifier''' (Ufm1) is a member of the ubiquitin-like family.  Ufm1 is covalently attached to Lys residues of substrate proteins<ref>PMID:21494687</ref>.  This attachment is called Ufmylation and requires  '''Ubiquitin-like modifier activating enzyme''' (Uba5) and '''Ufm1-conjugating enzyme''' (Ufc1).  Ufmylation is a type of post-translational modification that deals with fine-tuned and complex cellular activities and is involved in reticulophagy induced by ER stress<ref>PMID:31129212</ref>.  Ufmylation is aribosomal modification specialized to facilitate metazoan-specific protein biogenesis at the ER<ref>PMID:30626644</ref>.
 == Relevance ==
@@ Line 9: / Line 11: @@
 <scene name='87/873802/Cv/2'>The 3D structure of the complex between Ufm1 and UBA</scene> shows the Ufm1 critical binding sequence and the <scene name='87/873802/Cv/4'>interactions between the 2 modifying enzymes</scene> <ref>PMID:27653677</ref>.
-</StructureSection>
 == 3D Structures of Ubiquitin-fold modifier ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+[[Ubiquitin-fold modifier 3D structures]]
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Ubiquitin-fold modifier
-**[[5ia7]] – hUfm1 - human<br />
-**[[1wxs]] – hUfm1 - NMR<br />
-**[[5hkh]] – hUfm1 + peptide<br />
-**[[5iaa]] – hUfm1 + UBA5<br />
-**[[5l95]] – hUfm1 + UBA5 + AMP<br />
-**[[6h77]] – hUfm1 + UBA5 + ATP<br />
-**[[5xda]] – Ufm1 + Umf1-specific protease - ''Caenorhabditis elegans''<br />
-**[[6izg]] – Ufm1 - ''Trypanosoma brucei'' - NMR<br />
-*Umf1-conjugating enzyme
-**[[2z6o]], [[2z6p]], [[3evx]] – hUfc1<br />
-**[[2k07]] – hUfc1 - NMR<br />
-*Ubiquitin-like modifier activating enzyme
-**[[3h8v]], [[6h78]] – hUBA5 + ATP<br />
-**[[3guc]] – hUBA5 + AMPPNP<br />
-}}
 ==References==
 <references />
+</StructureSection>
 [[Category:Topic Page]]