Rabphilin: Difference between revisions
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<StructureSection load='5lob' size='340' side='right' caption='Structure of rabphilin-3A C2B domain (green, grey, pink) complex with SNAP-25 N-terminal helix (yellow, magenta), glycerol, sulfate and Ca+2 ions (PDB code [[5lob]])' scene=''> | <StructureSection load='5lob' size='340' side='right' caption='Structure of rabphilin-3A C2B domain (green, grey, pink) complex with SNAP-25 N-terminal helix (yellow, magenta), glycerol, sulfate and Ca+2 ions (PDB code [[5lob]])' scene='87/873795/Cv/1'> | ||
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
The 3D structure of the complex between three Rab C2B domains and a 4-helix bundle belonging to | <scene name='87/873795/Cv/2'>The 3D structure of the complex between three Rab C2B domains and a 4-helix bundle belonging to 4 SNAP-25 monomers</scene>. Two different <scene name='87/873795/Cv/6'>helix-helix interactions between Rab and SNAP-25</scene> are seen. One involves 2 monomers of SNAP-25 and the other involves one monomer<ref>PMID:28634303</ref>. Rab chain A interacts only with SNAP-25 chain D, while Rab chain B interacts with 2 SNAP-25 chains D (residues that interact with Rab chain B are colored salmon) and F. | ||
</StructureSection> | </StructureSection> | ||
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[[2cm5]], [[2cm6]] – rRab C2B domain – rat<br /> | [[2cm5]], [[2cm6]] – rRab C2B domain – rat<br /> | ||
[[4izk]] – rRab C2B domain - NMR<br /> | [[3rpb]], [[4izk]] – rRab C2B domain - NMR<br /> | ||
[[5lo8]] – rRab C2B domain + inositol phosphate derivative<br /> | [[5lo8]] – rRab C2B domain + inositol phosphate derivative<br /> | ||
[[5lob]], [[5low]] – rRab C2B domain + SNAP25<br /> | [[5lob]], [[5low]] – rRab C2B domain + SNAP25<br /> | ||
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[[1zbd]] – rRab 19-217 (mutant) + rRab effector domain 40-179 (mutant) + GTP<br /> | [[1zbd]] – rRab 19-217 (mutant) + rRab effector domain 40-179 (mutant) + GTP<br /> | ||
[[2k3h]] – mRab C2A domain - mouse - NMR<br /> | [[2k3h]] – mRab C2A domain - mouse - NMR<br /> | ||
== References == | == References == | ||
Latest revision as of 10:15, 5 October 2023
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3D Structures of rabphilin 3-A
Updated on 05-October-2023
Domains: C2A 378-510; C2B 541-680
2cm5, 2cm6 – rRab C2B domain – rat
3rpb, 4izk – rRab C2B domain - NMR
5lo8 – rRab C2B domain + inositol phosphate derivative
5lob, 5low – rRab C2B domain + SNAP25
2chd, 4lt7 – rRab C2A domain
4np9, 4ns0 – rRab C2A domain + inositol phosphate derivative
1zbd – rRab 19-217 (mutant) + rRab effector domain 40-179 (mutant) + GTP
2k3h – mRab C2A domain - mouse - NMR
