2o40: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
New page: left|200px<br /> <applet load="2o40" size="450" color="white" frame="true" align="right" spinBox="true" caption="2o40, resolution 1.65Å" /> '''Crystal Structure o...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(15 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2o40.gif|left|200px]]<br />
<applet load="2o40" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2o40, resolution 1.65&Aring;" />
'''Crystal Structure of a Chemically Synthesized 203 Amino Acid 'Covalent Dimer' HIV-1 Protease Molecule'''<br />


==About this Structure==
==Crystal Structure of a Chemically Synthesized 203 Amino Acid 'Covalent Dimer' HIV-1 Protease Molecule==
2O40 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with ACE as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2O40 OCA].  
<StructureSection load='2o40' size='340' side='right'caption='[[2o40]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2o40]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O40 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2NC:N-{(2S)-2-[(N-ACETYL-L-THREONYL-L-ISOLEUCYL)AMINO]HEXYL}-L-NORLEUCYL-L-GLUTAMINYL-N~5~-[AMINO(IMINIO)METHYL]-L-ORNITHINAMIDE'>2NC</scene>, <scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o40 OCA], [https://pdbe.org/2o40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o40 RCSB], [https://www.ebi.ac.uk/pdbsum/2o40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o40 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O38716_9HIV1 O38716_9HIV1]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o4/2o40_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o40 ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
Convergent chemical synthesis and crystal structure of a 203 amino acid "covalent dimer" HIV-1 protease enzyme molecule., Torbeev VY, Kent SB, Angew Chem Int Ed Engl. 2007;46(10):1667-70. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17397076 17397076]
*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
[[Category: HIV-1 retropepsin]]
__TOC__
[[Category: Protein complex]]
</StructureSection>
[[Category: Kent, S.B.H.]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Torbeev, V.Y.]]
[[Category: Large Structures]]
[[Category: ACE]]
[[Category: Kent SBH]]
[[Category: beta-turn]]
[[Category: Torbeev VY]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov  8 14:54:34 2007''
Retrieved from "https://proteopedia.org/2o40"