7lhx: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 7lhx is ~~ON HOLD until Paper Publication~~

==Human U1A protein with F37M and F77M mutations for improved phasing==

== Structural highlights ==

<table><tr><td colspan='2'>[[7lhx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LHX OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7LHX FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7lhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lhx OCA], [https://pdbe.org/7lhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lhx RCSB], [https://www.ebi.ac.uk/pdbsum/7lhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lhx ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>

~~Authors~~:

==See Also==

*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]

~~Description~~:

== References ==

[[Category: ~~Unreleased Structures~~]]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Jenkins JL]]

[[Category: Lippa GM]]

[[Category: Wedekind JE]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7lhx is ON HOLD  until Paper Publication
+==Human U1A protein with F37M and F77M mutations for improved phasing==
+<StructureSection load='7lhx' size='340' side='right'caption='[[7lhx]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7lhx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LHX FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lhx OCA], [https://pdbe.org/7lhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lhx RCSB], [https://www.ebi.ac.uk/pdbsum/7lhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lhx ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
-Authors:
+==See Also==
+*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
-Description:
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Jenkins JL]]
+[[Category: Lippa GM]]
+[[Category: Wedekind JE]]