1e3k: Difference between revisions

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<StructureSection load='1e3k' size='340' side='right'caption='[[1e3k]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='1e3k' size='340' side='right'caption='[[1e3k]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1e3k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E3K FirstGlance]. <br>
<table><tr><td colspan='2'>[[1e3k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E3K FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R18:(17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE'>R18</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a28|1a28]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R18:(17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE'>R18</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3k OCA], [https://pdbe.org/1e3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e3k RCSB], [https://www.ebi.ac.uk/pdbsum/1e3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e3k ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3k OCA], [https://pdbe.org/1e3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e3k RCSB], [https://www.ebi.ac.uk/pdbsum/1e3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e3k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN]] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref>  Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref>
[https://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref>  Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Basler, S]]
[[Category: Basler S]]
[[Category: Carrondo, M A]]
[[Category: Carrondo MA]]
[[Category: Coelho, R]]
[[Category: Coelho R]]
[[Category: Donner, P]]
[[Category: Donner P]]
[[Category: Egner, U]]
[[Category: Egner U]]
[[Category: Joschko, S]]
[[Category: Joschko S]]
[[Category: Macedo, S]]
[[Category: Macedo S]]
[[Category: Matias, P M]]
[[Category: Matias PM]]
[[Category: Otto, N]]
[[Category: Otto N]]
[[Category: Peixoto, C]]
[[Category: Peixoto C]]
[[Category: Schafer, M]]
[[Category: Schafer M]]
[[Category: Scholz, P]]
[[Category: Scholz P]]
[[Category: Thomaz, M]]
[[Category: Thomaz M]]
[[Category: Wegg, A]]
[[Category: Wegg A]]
[[Category: Human progesterone receptor]]
[[Category: Ligand binding domain]]
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