7e5n: Difference between revisions

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New page: '''Unreleased structure''' The entry 7e5n is ON HOLD Authors: Description: Category: Unreleased Structures
 
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'''Unreleased structure'''


The entry 7e5n is ON HOLD
==crystal structure of cis assembled TROP-2==
<StructureSection load='7e5n' size='340' side='right'caption='[[7e5n]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E5N FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e5n OCA], [https://pdbe.org/7e5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e5n RCSB], [https://www.ebi.ac.uk/pdbsum/7e5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e5n ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Human trophoblast cell surface antigen 2 (TROP-2) is an important target of tumor therapy, and antibody-drug conjugates with sacituzumab targeting TROP-2 have been approved for the treatment of triple-negative breast cancer. Here, we report the crystal structures of TROP-2-ECD, which can be either cis- or trans-dimers depending on which distinct but overlapping interfaces is used to engage with monomers. The cis- or trans-tetrameric forms of TROP-2 can also be assembled with a non-overlapping interface with either cis- or trans-dimerization, suggesting that cis- and trans-dimers cluster on the cell surface. The binding site of sacituzumab on TROP-2 is mapped to be located on a stretched polypeptide in CPD (Q237-Q252), which is not involved in either cis- or trans-interactions. The present findings will improve understanding of the molecular assembly of TROP-2 on tumor cells and shed light on future design of biologics for tumor therapy.


Authors:  
Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2.,Sun M, Zhang H, Jiang M, Chai Y, Qi J, Gao GF, Tan S iScience. 2021 Sep 30;24(10):103190. doi: 10.1016/j.isci.2021.103190. eCollection, 2021 Oct 22. PMID:34693228<ref>PMID:34693228</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 7e5n" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Chai Y]]
[[Category: Gao GF]]
[[Category: Qi J]]
[[Category: Sun M]]
[[Category: Tan S]]
[[Category: Zhang H]]
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