1br9: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[1br9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BR9 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=1BR9 FirstGlance].

<table><tr><td colspan='2'>[[1br9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BR9 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=1BR9 FirstGlance].

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=1br9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1br9 OCA], [https://pdbe.org/1br9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1br9 RCSB], [https://www.ebi.ac.uk/pdbsum/1br9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1br9 ProSAT]</td></tr>

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=1br9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1br9 OCA], [https://pdbe.org/1br9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1br9 RCSB], [https://www.ebi.ac.uk/pdbsum/1br9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1br9 ProSAT]</td></tr>

</table>

== Function ==

[[https://www.uniprot.org/uniprot/TIMP2_HUMAN TIMP2_HUMAN]] Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.<ref>PMID:2793861</ref> <ref>PMID:2554304</ref> <ref>PMID:11710594</ref>

[https://www.uniprot.org/uniprot/TIMP2_HUMAN TIMP2_HUMAN] Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.<ref>PMID:2793861</ref> <ref>PMID:2554304</ref> <ref>PMID:11710594</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/br/1br9_consurf.spt"</scriptWhenChecked>

<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>

<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>

<text>to colour the structure by Evolutionary Conservation</text>

</jmolCheckbox>

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__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Bergmann, U]]

[[Category: Bergmann U]]

[[Category: Lindqvist, Y]]

[[Category: Lindqvist Y]]

[[Category: Morgunova, E]]

[[Category: Morgunova E]]

[[Category: Schneider, G]]

[[Category: Schneider G]]

[[Category: Tryggvason, K]]

[[Category: Tryggvason K]]

[[Category: Tuuttila, A]]

[[Category: Tuuttila A]]

~~[[Category: Proteinase inhibitor~~]]

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@@ Line 3: / Line 3: @@
 <StructureSection load='1br9' size='340' side='right'caption='[[1br9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1br9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BR9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1br9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BR9 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1br9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1br9 OCA], [https://pdbe.org/1br9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1br9 RCSB], [https://www.ebi.ac.uk/pdbsum/1br9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1br9 ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1br9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1br9 OCA], [https://pdbe.org/1br9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1br9 RCSB], [https://www.ebi.ac.uk/pdbsum/1br9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1br9 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/TIMP2_HUMAN TIMP2_HUMAN]] Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.<ref>PMID:2793861</ref> <ref>PMID:2554304</ref> <ref>PMID:11710594</ref>
+[https://www.uniprot.org/uniprot/TIMP2_HUMAN TIMP2_HUMAN] Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.<ref>PMID:2793861</ref> <ref>PMID:2554304</ref> <ref>PMID:11710594</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 13: / Line 14: @@
    <jmolCheckbox>
      <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/br/1br9_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
@@ Line 31: / Line 32: @@
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Bergmann, U]]
+[[Category: Bergmann U]]
-[[Category: Lindqvist, Y]]
+[[Category: Lindqvist Y]]
-[[Category: Morgunova, E]]
+[[Category: Morgunova E]]
-[[Category: Schneider, G]]
+[[Category: Schneider G]]
-[[Category: Tryggvason, K]]
+[[Category: Tryggvason K]]
-[[Category: Tuuttila, A]]
+[[Category: Tuuttila A]]
-[[Category: Proteinase inhibitor]]