Domain: Difference between revisions

(One intermediate revision by the same user not shown)

Line 1:

A protein ''domain'' usually means a sequence of amino acids that folds, independently of the remainder of the full-length sequence, into a compact stable structure. Water-soluble domains typically have hydrophobic cores. Some small full-length proteins consist of a single domain, but ~~most~~ proteins have two or more domains. A domain is typically 100-250 amino acids in length<ref name="EPR" />, but can sometimes be shorter or longer.

A protein ''domain'' usually means a sequence of amino acids that folds, independently of the remainder of the full-length sequence, into a compact stable structure. Water-soluble domains typically have hydrophobic cores. Some small full-length proteins consist of a single domain, but many proteins have two or more domains. A domain is typically 100-250 amino acids in length<ref name="EPR" />, but can sometimes be shorter or longer.

In 2006, chains with a single domain in the CATH database had an average length of 159<ref name="cath2006">PMID: 17135200</ref>.

In 2006, chains with a single domain in the CATH database had an average length of 159<ref name="cath2006">PMID: 17135200</ref>. In 2006, 64% of all protein structures in CATH were single domain chains. 27% were two-domain chains<ref name="cath2006" />.

Examples:

Line 12:

* [[2hhd]]: Each of the 4 chains that form hemoglobin (a tetramer) folds into a single domain composed of alpha-helices. Each domain (chain) is 141-146 amino acids in length for human hemoglobin.

* [[1igy]]: Immunoglobulin G (antibody) consists of 12 domains in 4 chains. These domains are composed of beta-sheets. Each of the two heavy chains has 4 domains, and each of the 2 light chains has 2 domains. These domains are about 110 amino acids in length. Each heavy chain has two pairs of domains connected by a flexible linker about 20 amino acids in length.

* [[1igy]]: Immunoglobulin G (antibody) consists of 12 domains in 4 chains. These ''immunoglobulin superfamily'' domains are composed of beta-sheets. Each of the two heavy chains has 4 domains, and each of the 2 light chains has 2 domains. These domains are about 110 amino acids in length. Each heavy chain has two pairs of domains connected by a flexible linker about 20 amino acids in length.

For more information see [http://www.wikipedia.com/wiki/Protein_domain Protein Domain in Wikipedia].

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
 {{Stub}}
-A protein ''domain'' usually means a sequence of amino acids that folds, independently of the remainder of the full-length sequence, into a compact stable structure. Water-soluble domains typically have hydrophobic cores. Some small full-length proteins consist of a single domain, but most proteins have two or more domains. A domain is typically 100-250 amino acids in length<ref name="EPR" />, but can sometimes be shorter or longer.
+A protein ''domain'' usually means a sequence of amino acids that folds, independently of the remainder of the full-length sequence, into a compact stable structure. Water-soluble domains typically have hydrophobic cores. Some small full-length proteins consist of a single domain, but many proteins have two or more domains. A domain is typically 100-250 amino acids in length<ref name="EPR" />, but can sometimes be shorter or longer.
-In 2006, chains with a single domain in the CATH database had an average length of 159<ref name="cath2006">PMID: 17135200</ref>.
+In 2006, chains with a single domain in the CATH database had an average length of 159<ref name="cath2006">PMID: 17135200</ref>. In 2006, 64% of all protein structures in CATH were single domain chains. 27% were two-domain chains<ref name="cath2006" />.
 Examples:
@@ Line 12: / Line 12: @@
 * [[2hhd]]: Each of the 4 chains that form hemoglobin (a tetramer) folds into a single domain composed of alpha-helices. Each domain (chain) is 141-146 amino acids in length for human hemoglobin.
-* [[1igy]]: Immunoglobulin G (antibody) consists of 12 domains in 4 chains. These domains are composed of beta-sheets. Each of the two heavy chains has 4 domains, and each of the 2 light chains has 2 domains. These domains are about 110 amino acids in length. Each heavy chain has two pairs of domains connected by a flexible linker about 20 amino acids in length.
+* [[1igy]]: Immunoglobulin G (antibody) consists of 12 domains in 4 chains. These ''immunoglobulin superfamily'' domains are composed of beta-sheets. Each of the two heavy chains has 4 domains, and each of the 2 light chains has 2 domains. These domains are about 110 amino acids in length. Each heavy chain has two pairs of domains connected by a flexible linker about 20 amino acids in length.
 For more information see [http://www.wikipedia.com/wiki/Protein_domain Protein Domain in Wikipedia].