6lu5: Difference between revisions
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==Crystal structure of BPTF-BRD with ligand DCBPin5 bound== | |||
<StructureSection load='6lu5' size='340' side='right'caption='[[6lu5]], [[Resolution|resolution]] 1.87Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6lu5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LU5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LU5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8652773Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EUO:6-(1H-indol-5-yl)-N-methyl-2-methylsulfonyl-pyrimidin-4-amine'>EUO</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lu5 OCA], [https://pdbe.org/6lu5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lu5 RCSB], [https://www.ebi.ac.uk/pdbsum/6lu5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lu5 ProSAT]</span></td></tr> | ||
[[Category: Lu | </table> | ||
[[Category: Lu | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Lin H]] | |||
[[Category: Lu HB]] | |||
[[Category: Lu T]] | |||
[[Category: Lu W]] | |||
[[Category: Luo C]] | |||
[[Category: Wang J]] | |||
Latest revision as of 14:53, 29 November 2023
Crystal structure of BPTF-BRD with ligand DCBPin5 bound
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