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==X-ray structure of Arsenoplatin-1-encapsulated horse spleen ferritin==
==X-ray structure of Arsenoplatin-1-encapsulated horse spleen ferritin==
<StructureSection load='7bd7' size='340' side='right'caption='[[7bd7]]' scene=''>
<StructureSection load='7bd7' size='340' side='right'caption='[[7bd7]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BD7 FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BD7 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bd7 OCA], [https://pdbe.org/7bd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bd7 RCSB], [https://www.ebi.ac.uk/pdbsum/7bd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bd7 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A6R:arsenoplatin-1'>A6R</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bd7 OCA], [https://pdbe.org/7bd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bd7 RCSB], [https://www.ebi.ac.uk/pdbsum/7bd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bd7 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Arsenoplatin-1 (AP-1), the prototype of a novel class of metallodrugs containing a PtAs(OH)2 core, was encapsulated within the apoferritin (AFt) nanocage. UV-Vis absorption spectroscopy and inductively coupled plasma-atomic emission spectroscopy measurements confirmed metallodrug encapsulation and allowed us to determine the average amount of AP-1 trapped inside the cage. The X-ray structure of AP-1-encapsulated AFt was solved at 1.50 A. Diffraction data revealed that an AP-1 fragment coordinates the side chain of a His residue. The biological activity of AP-1-loaded AFt was comparatively tested on a few representative cancer and non-cancer cell lines. Even though the presence of the cage reduces the overall cytotoxicity of AP-1, it improves its selectivity towards cancer cells.
Arsenoplatin-Ferritin Nanocage: Structure and Cytotoxicity.,Ferraro G, Pratesi A, Cirri D, Imbimbo P, Maria Monti D, Messori L, Merlino A Int J Mol Sci. 2021 Feb 13;22(4). pii: ijms22041874. doi: 10.3390/ijms22041874. PMID:33668605<ref>PMID:33668605</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7bd7" style="background-color:#fffaf0;"></div>
==See Also==
*[[Ferritin 3D structures|Ferritin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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