7m2o: Difference between revisions
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==Crystal structure of Human Glycolate Oxidase with Inhibitor Compound 15== | |||
<StructureSection load='7m2o' size='340' side='right'caption='[[7m2o]], [[Resolution|resolution]] 2.07Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7m2o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M2O FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=YOJ:5-[(5-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-3-yl}-2-fluoro[1,1-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic+acid'>YOJ</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m2o OCA], [https://pdbe.org/7m2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m2o RCSB], [https://www.ebi.ac.uk/pdbsum/7m2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m2o ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HAOX1_HUMAN HAOX1_HUMAN] Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. | |||
==See Also== | |||
*[[Glycolate oxidase 3D structures|Glycolate oxidase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ding J]] | |||
[[Category: Gumpena R]] | |||
[[Category: Lowther WT]] | |||
[[Category: Powell DA]] | |||
Latest revision as of 16:04, 18 October 2023
Crystal structure of Human Glycolate Oxidase with Inhibitor Compound 15
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