1fhq: Difference between revisions
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==REFINED SOLUTION STRUCTURE OF THE FHA2 DOMAIN OF RAD53== | ==REFINED SOLUTION STRUCTURE OF THE FHA2 DOMAIN OF RAD53== | ||
<StructureSection load='1fhq' size='340' side='right'caption='[[1fhq | <StructureSection load='1fhq' size='340' side='right'caption='[[1fhq]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1fhq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FHQ FirstGlance]. <br> | <table><tr><td colspan='2'>[[1fhq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FHQ FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fhq OCA], [https://pdbe.org/1fhq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fhq RCSB], [https://www.ebi.ac.uk/pdbsum/1fhq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fhq ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fhq OCA], [https://pdbe.org/1fhq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fhq RCSB], [https://www.ebi.ac.uk/pdbsum/1fhq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fhq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/RAD53_YEAST RAD53_YEAST] Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. Seems to be involved in the phosphorylation of RPH1.<ref>PMID:8355715</ref> <ref>PMID:7958905</ref> <ref>PMID:10550056</ref> <ref>PMID:11809875</ref> <ref>PMID:15024067</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Byeon | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Liao | [[Category: Byeon I-JL]] | ||
[[Category: Tsai | [[Category: Liao H]] | ||
[[Category: Tsai M-D]] | |||
