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==THE NUCLEAR MAGNETIC RESONANCE SOLUTION STRUCTURE OF FLAVORIDIN, AN ANTAGONIST OF THE PLATELET GP IIB-IIIA RECEPTOR==
==THE NUCLEAR MAGNETIC RESONANCE SOLUTION STRUCTURE OF FLAVORIDIN, AN ANTAGONIST OF THE PLATELET GP IIB-IIIA RECEPTOR==
<StructureSection load='1fvl' size='340' side='right'caption='[[1fvl]], [[NMR_Ensembles_of_Models | 18 NMR models]]' scene=''>
<StructureSection load='1fvl' size='340' side='right'caption='[[1fvl]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1fvl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trimeresurus_flavoviridis Trimeresurus flavoviridis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FVL FirstGlance]. <br>
<table><tr><td colspan='2'>[[1fvl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Protobothrops_flavoviridis Protobothrops flavoviridis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FVL FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fvl OCA], [https://pdbe.org/1fvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fvl RCSB], [https://www.ebi.ac.uk/pdbsum/1fvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fvl ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 18 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fvl OCA], [https://pdbe.org/1fvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fvl RCSB], [https://www.ebi.ac.uk/pdbsum/1fvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fvl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/VM2FL_PROFL VM2FL_PROFL]] Snake venom metalloproteinase: impairs hemostasis in the envenomed animal.  Disintegrin flavoridin: inhibits platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3) (By similarity).  
[https://www.uniprot.org/uniprot/VM2FL_PROFL VM2FL_PROFL] Snake venom metalloproteinase: impairs hemostasis in the envenomed animal.  Disintegrin flavoridin: inhibits platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3) (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/1fvl_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/1fvl_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Trimeresurus flavoviridis]]
[[Category: Protobothrops flavoviridis]]
[[Category: Klaus, W]]
[[Category: Klaus W]]
[[Category: Senn, H]]
[[Category: Senn H]]
[[Category: Blood coagulation inhibitor]]
[[Category: Gp iib/iiia antagonist]]
Retrieved from "https://proteopedia.org/1fvl"