7o1h: Difference between revisions
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==Hybrid-2R quadruplex-duplex with (-p-p-l) topology and 3 syn residues== | |||
<StructureSection load='7o1h' size='340' side='right'caption='[[7o1h]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O1H FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o1h OCA], [https://pdbe.org/7o1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o1h RCSB], [https://www.ebi.ac.uk/pdbsum/7o1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o1h ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Canonical G-quadruplexes can adopt a variety of different topologies depending on the arrangement of propeller, lateral, or diagonal loops connecting the four G-columns. A novel intramolecular G-quadruplex structure is derived through inversion of the last G-tract of a three-layered parallel fold, associated with the transition of a single propeller into a lateral loop. The resulting (3+1) hybrid fold features three syn.anti.anti.anti G-tetrads with a 3'-terminal all- syn G-column. Although the ability of forming a duplex stem-loop between G-tracts seems beneficial for a propeller-to-lateral loop rearrangement, unmodified G-rich sequences resist folding into the new (3+1) topology. However, refolding can be driven by the incorporation of syn -favoring guanosine analogs into positions of the fourth G-stretch. The presented hybrid-type G-quadruplex structure as determined by NMR may provide for an additional scaffold in quadruplex-based technologies. | |||
Expanding the Topological Landscape by a G-Column Flip of a Parallel G-Quadruplex.,Mohr S, Jana J, Vianney YM, Weisz K Chemistry. 2021 May 6. doi: 10.1002/chem.202101181. PMID:33955615<ref>PMID:33955615</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 7o1h" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mohr S]] | |||
[[Category: Vianney YM]] | |||
[[Category: Weisz K]] | |||
Latest revision as of 06:13, 19 June 2024
Hybrid-2R quadruplex-duplex with (-p-p-l) topology and 3 syn residues
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