2iuo: Difference between revisions

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New page: left|200px<br /> <applet load="2iuo" size="450" color="white" frame="true" align="right" spinBox="true" caption="2iuo, resolution 1.90Å" /> '''SITE DIRECTED MUTAG...
 
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[[Image:2iuo.gif|left|200px]]<br />
<applet load="2iuo" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2iuo, resolution 1.90&Aring;" />
'''SITE DIRECTED MUTAGENESIS OF KEY RESIDUES INVOLVED IN THE CATALYTIC MECHANISM OF CYANASE'''<br />


==About this Structure==
==Site Directed Mutagenesis of Key Residues Involved in the Catalytic Mechanism of Cyanase==
2IUO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with BR, CL, SO4 and AZI as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.104 4.2.1.104]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IUO OCA]].  
<StructureSection load='2iuo' size='340' side='right'caption='[[2iuo]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2iuo]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IUO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iuo OCA], [https://pdbe.org/2iuo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iuo RCSB], [https://www.ebi.ac.uk/pdbsum/2iuo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iuo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CYNS_ECOLI CYNS_ECOLI] Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iu/2iuo_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iuo ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Anderson, M.P.]]
[[Category: Anderson MP]]
[[Category: Guilloton, M.]]
[[Category: Guilloton M]]
[[Category: Joachimiak, A.]]
[[Category: Joachimiak A]]
[[Category: Walsh, M.A.]]
[[Category: Walsh MA]]
[[Category: AZI]]
[[Category: BR]]
[[Category: CL]]
[[Category: SO4]]
[[Category: cyanate degradation]]
[[Category: lyase]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 17:58:47 2007''
Retrieved from "https://proteopedia.org/2iuo"