Induced fit: Difference between revisions

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[[Induced fit]] describes a conformational change in a protein when it binds a ligand, in contrast to a lock-and-key model of ligand binding. A ~~classical~~ example of induced fit is binding of glucose to hexokinase, depicted in a morph between [[3o8m]] and [[3o80]] ~~below~~.

[[Image:Induced fit.gif|frame|Morph of hexokinase in the open [[3o80]] and glucose-bound closed [[3o8m]] conformation. For reference, glucose (purple) is shown throughout the morph. Two views are shown, an overview as spacefill and a detail of the binding site in wireframe.]]

[[Induced fit]] describes a conformational change in a protein when it binds a ligand, in contrast to a lock-and-key model of ligand binding. A classic example of induced fit is binding of glucose to hexokinase, depicted in a morph between [[3o8m]] and [[3o80]] in the picture at right.

~~[[Image:Induced fit.gif]]~~

==History of the concept==

Line 10:

Line 11:

~~In preparation~~.

This is a [[morphs|morph]] of the <scene name='31/318562/Hexokinase/3'>closed and open form of hexokinase</scene> (be patient when loading this). The first and the last frame of the animation are models based on crystallographic data while the intermediate states are somewhat arbitrary, but chosen to show a smooth transition between conformations.

<jmol>

<item>

</item>

<item>

<text>Closed</text>

</item>

<item>

<text>Animated</text>

</item>

</jmolRadioGroup>

</jmol>

</StructureSection>

==See Also==

*A morph of induced fit when [[Avian_Influenza_Neuraminidase%2C_Tamiflu_and_Relenza#Tamiflu_Binds_to_N1_by_Induced_Fit|Tamiflu binds to Neuraminidase]].

== References ==

Induced fit: Difference between revisions

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@@ Line 1: / Line 1: @@
-[[Induced fit]] describes a conformational change in a protein when it binds a ligand, in contrast to a lock-and-key model of ligand binding. A classical example of induced fit is binding of glucose to hexokinase, depicted in a morph between [[3o8m]] and [[3o80]] below.
+[[Image:Induced fit.gif|frame|Morph of hexokinase in the open [[3o80]] and glucose-bound closed [[3o8m]] conformation. For reference, glucose (purple) is shown throughout the morph. Two views are shown, an overview as spacefill and a detail of the binding site in wireframe.]]
+[[Induced fit]] describes a conformational change in a protein when it binds a ligand, in contrast to a lock-and-key model of ligand binding. A classic example of induced fit is binding of glucose to hexokinase, depicted in a morph between [[3o8m]] and [[3o80]] in the picture at right.
-[[Image:Induced fit.gif]]
 ==History of the concept==
@@ Line 10: / Line 11: @@
 <StructureSection load='' size='350' side='right' caption='' scene=''>
-In preparation.
+This is a [[morphs|morph]] of the <scene name='31/318562/Hexokinase/3'>closed and open form of hexokinase</scene> (be patient when loading this). The first and the last frame of the animation are models based on crystallographic data while the intermediate states are somewhat arbitrary, but chosen to show a smooth transition between conformations.
+<jmol>
+  <jmolRadioGroup>
+    <item>
+      <script>anim off;model 1</script>
+      <text>Open</text>
+    </item>
+    <item>
+      <script>anim off;model 11</script>
+      <text>Closed</text>
+    </item>
+     <item>
+      <script>anim on;</script>
+      <text>Animated</text>
+      <checked>true</checked>
+    </item>
+   </jmolRadioGroup>
+</jmol>
 </StructureSection>
 ==See Also==
 *A morph of induced fit when [[Avian_Influenza_Neuraminidase%2C_Tamiflu_and_Relenza#Tamiflu_Binds_to_N1_by_Induced_Fit|Tamiflu binds to Neuraminidase]].
+== References ==
 <references/>