1aa2: Difference between revisions

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New page: left|200px<br /> <applet load="1aa2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1aa2, resolution 2.0Å" /> '''CALPONIN HOMOLOGY (C...
 
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[[Image:1aa2.gif|left|200px]]<br />
<applet load="1aa2" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1aa2, resolution 2.0&Aring;" />
'''CALPONIN HOMOLOGY (CH) DOMAIN FROM HUMAN BETA-SPECTRIN'''<br />


==Overview==
==CALPONIN HOMOLOGY (CH) DOMAIN FROM HUMAN BETA-SPECTRIN==
The three-dimensional structure of the calponin homology domain present in, many actin binding cytoskeletal and signal-transducing proteins has been, determined at 2.0 A resolution.
<StructureSection load='1aa2' size='340' side='right'caption='[[1aa2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1aa2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AA2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aa2 OCA], [https://pdbe.org/1aa2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aa2 RCSB], [https://www.ebi.ac.uk/pdbsum/1aa2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aa2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPTB2_HUMAN SPTB2_HUMAN] Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aa/1aa2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aa2 ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1AA2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AA2 OCA].
*[[Spectrin 3D structures|Spectrin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
Crystal structure of a calponin homology domain., Carugo KD, Banuelos S, Saraste M, Nat Struct Biol. 1997 Mar;4(3):175-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9164454 9164454]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Banuelos, S.]]
[[Category: Banuelos S]]
[[Category: Carugo, K.Djinovic.]]
[[Category: Djinovic Carugo K]]
[[Category: Saraste, M.]]
[[Category: Saraste M]]
[[Category: cytoskeleton]]
[[Category: f-actin cross-linking]]
[[Category: spectrin]]
 
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