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==SOLUTION STRUCTURE OF CARDIOTOXIN IV, NMR, 12 STRUCTURES==
==SOLUTION STRUCTURE OF CARDIOTOXIN IV, NMR, 12 STRUCTURES==
<StructureSection load='1kbt' size='340' side='right'caption='[[1kbt]], [[NMR_Ensembles_of_Models | 12 NMR models]]' scene=''>
<StructureSection load='1kbt' size='340' side='right'caption='[[1kbt]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1kbt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chinese_cobra Chinese cobra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KBT FirstGlance]. <br>
<table><tr><td colspan='2'>[[1kbt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KBT FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1kbs|1kbs]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 12 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kbt OCA], [https://pdbe.org/1kbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kbt RCSB], [https://www.ebi.ac.uk/pdbsum/1kbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kbt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kbt OCA], [https://pdbe.org/1kbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kbt RCSB], [https://www.ebi.ac.uk/pdbsum/1kbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kbt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/3SA4_NAJAT 3SA4_NAJAT]] Basic protein that bind to cell membrane and depolarizes cardiomyocytes. This cytotoxin also shows lytic activities, but 2-fold more important than that of CTX-A2. It binds to the integrin alpha-V/beta-3 with a moderate affinity. Inhibits protein kinase C. It may interact with sulfatides in the cell membrane, which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induces mitochondrial swelling and fragmentation.<ref>PMID:16407244</ref> <ref>PMID:8448165</ref> <ref>PMID:9398182</ref>
[https://www.uniprot.org/uniprot/3SA4_NAJAT 3SA4_NAJAT] Basic protein that bind to cell membrane and depolarizes cardiomyocytes. This cytotoxin also shows lytic activities, but 2-fold more important than that of CTX-A2. It binds to the integrin alpha-V/beta-3 with a moderate affinity. Inhibits protein kinase C. It may interact with sulfatides in the cell membrane, which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induces mitochondrial swelling and fragmentation.<ref>PMID:16407244</ref> <ref>PMID:8448165</ref> <ref>PMID:9398182</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/1kbt_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/1kbt_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chinese cobra]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Jayaraman, G]]
[[Category: Naja atra]]
[[Category: Jeng, J Y]]
[[Category: Jayaraman G]]
[[Category: Kumar, T K.S]]
[[Category: Jeng JY]]
[[Category: Yu, C]]
[[Category: Kumar TKS]]
[[Category: Cardiotoxin]]
[[Category: Yu C]]
[[Category: Cytotoxin]]
[[Category: Multigene family]]
[[Category: Venom]]
Retrieved from "https://proteopedia.org/1kbt"