Sandbox GGC16: Difference between revisions

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Myeloid Leukemia. Blood. 2003, 101(5), 2074–2074.</ref> It is highly polar due to the abundance of proline, glutamate, serine, and threonine. Proteins with a PEST region typically have a short half-life of under 2 hours. It is believed that the PEST region is a tag for fast degradation of the protein. This mutation likely provides a mechanism for the protein to evade degradation, enabling it to continue inducing transcription. This could contribute to cancerous growth of white blood cells.  
Myeloid Leukemia. Blood. 2003, 101(5), 2074–2074.</ref> It is highly polar due to the abundance of proline, glutamate, serine, and threonine. Proteins with a PEST region typically have a short half-life of under 2 hours. It is believed that the PEST region is a tag for fast degradation of the protein. This mutation likely provides a mechanism for the protein to evade degradation, enabling it to continue inducing transcription. This could contribute to cancerous growth of white blood cells.  


== Hydration Is Essential to PU.1/DNA Interaction ==


Water mediates the binding of PU.1 to DNA. As betaine was titrated into a solution of PU.1 and DNA, binding significantly decreased.


== References ==
== References ==
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