7o9y: Difference between revisions
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New page: '''Unreleased structure''' The entry 7o9y is ON HOLD until Paper Publication Authors: Livnah, O., Domovich, Y., Bracher, F., Aiger, C. Description: Crystal structure of di-phosphorylat... |
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==Crystal structure of di-phosphorylated human CLK1 in complex with 4-(1H-indol-3-yl)pyrimidin-2-amine== | |||
<StructureSection load='7o9y' size='340' side='right'caption='[[7o9y]], [[Resolution|resolution]] 1.66Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7o9y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O9Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O9Y FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=V5T:4-(1~{H}-indol-3-yl)pyrimidin-2-amine'>V5T</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o9y OCA], [https://pdbe.org/7o9y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o9y RCSB], [https://www.ebi.ac.uk/pdbsum/7o9y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o9y ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CLK1_HUMAN CLK1_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref> | |||
==See Also== | |||
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Aiger | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Livnah | [[Category: Large Structures]] | ||
[[Category: Aiger C]] | |||
[[Category: Bracher F]] | |||
[[Category: Domovich Y]] | |||
[[Category: Livnah O]] | |||
Latest revision as of 12:47, 1 February 2024
Crystal structure of di-phosphorylated human CLK1 in complex with 4-(1H-indol-3-yl)pyrimidin-2-amine
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