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==SOLUTION STRUCTURE OF THE LEXA REPRESSOR DNA BINDING DETERMINED BY 1H NMR SPECTROSCOPY==
==SOLUTION STRUCTURE OF THE LEXA REPRESSOR DNA BINDING DETERMINED BY 1H NMR SPECTROSCOPY==
<StructureSection load='1leb' size='340' side='right'caption='[[1leb]], [[NMR_Ensembles_of_Models | 28 NMR models]]' scene=''>
<StructureSection load='1leb' size='340' side='right'caption='[[1leb]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1leb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LEB FirstGlance]. <br>
<table><tr><td colspan='2'>[[1leb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LEB FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lea|1lea]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1leb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1leb OCA], [https://pdbe.org/1leb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1leb RCSB], [https://www.ebi.ac.uk/pdbsum/1leb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1leb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1leb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1leb OCA], [https://pdbe.org/1leb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1leb RCSB], [https://www.ebi.ac.uk/pdbsum/1leb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1leb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/LEXA_ECOLI LEXA_ECOLI]] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.<ref>PMID:7027255</ref> <ref>PMID:7027256</ref>
[https://www.uniprot.org/uniprot/LEXA_ECOLI LEXA_ECOLI] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.<ref>PMID:7027255</ref> <ref>PMID:7027256</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Boelens, R]]
[[Category: Boelens R]]
[[Category: Fogh, R H]]
[[Category: Fogh RH]]
[[Category: Kaptein, R]]
[[Category: Kaptein R]]
[[Category: Ottleben, G]]
[[Category: Ottleben G]]
[[Category: Rueterjans, H]]
[[Category: Rueterjans H]]
[[Category: Schnarr, M]]
[[Category: Schnarr M]]
[[Category: Transcription regulation]]
Retrieved from "https://proteopedia.org/1leb"