Postsynaptic density protein: Difference between revisions

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== PSD-95 ==

<StructureSection load='2XKX' size='340' side='right' caption='Apologies, these domains have not been ~~crystalized~~ into one structure yet so the models that will be seen are all individual pieces of the whole molecule. As such this page is more of an over look into the individual pieces of PSD-95 rather than the entirety of PSD-95~~.=''>~~

Apologies, these domains have not been crystallized into one structure yet so the models that will be seen are all individual pieces of the whole molecule. As such this page is more of an over look into the individual pieces of PSD-95 rather than the entirety of PSD-95

== Function ==

PSD-95 is a scaffolding protein that is found in the postsynaptic density (PSD) in the excitatory neurons of the cerebral cortex. This protein belongs to the Membrane-associated guanylate kinases (MAGUK) family. The proteins of the MAGUK family have been found to be a key factor in many processes. These processes include the development of tissues, communications between cells, cellular charge activation, and signal transduction between cells just to name a few. <ref> DOI: 10.1038/emboj.2011.428 </ref> PSD-95 permeates the PSD, a large curved protein complex that lines the postsynaptic membrane (PSM) or the cellular interior of a synapse. This protein complex’s primary function is one of support. It is known to hold not only synaptic receptors in place in the membrane but it holds their respective ~~signaling~~ molecules as well. PSD-95 is integral to the organization of these receptors, as well as the downstream ~~signaling~~ proteins. Due to the scaffolding directive of PSD-95, its structure is actually a series of proteins to make a much larger binding protein complex. PSD-95 not only enriches synaptic transmissions but it is also known to play a major role in synaptic plasticity through the lattice it makes at the synaptic membrane.

'''PSD-95''' or '''postsynaptic density protein 95''' or '''disks large homolog 4''' is a scaffolding protein that is found in the postsynaptic density (PSD) in the excitatory neurons of the cerebral cortex. This protein belongs to the Membrane-associated guanylate kinases (MAGUK) family. The proteins of the MAGUK family have been found to be a key factor in many processes. These processes include the development of tissues, communications between cells, cellular charge activation, and signal transduction between cells just to name a few. <ref> DOI: 10.1038/emboj.2011.428 </ref> PSD-95 permeates the PSD, a large curved protein complex that lines the postsynaptic membrane (PSM) or the cellular interior of a synapse. This protein complex’s primary function is one of support. It is known to hold not only synaptic receptors in place in the membrane but it holds their respective signalling molecules as well. PSD-95 is integral to the organization of these receptors, as well as the downstream signalling proteins. Due to the scaffolding directive of PSD-95, its structure is actually a series of proteins to make a much larger binding protein complex. PSD-95 not only enriches synaptic transmissions but it is also known to play a major role in synaptic plasticity through the lattice it makes at the synaptic membrane.

With PSD-95 being so close to the cell membrane, it can be identified and labeled by antibodies from both sides of the plasma membrane. Due to its location it is able to interact with membrane bound proteins including ion channels, adhesion molecules, and various receptors. The most important of these interactions is considered to be its ability to sort ~~signaling~~ complexes in the plasma membrane.

With PSD-95 being so close to the cell membrane, it can be identified and labeled by antibodies from both sides of the plasma membrane. Due to its location it is able to interact with membrane bound proteins including ion channels, adhesion molecules, and various receptors. The most important of these interactions is considered to be its ability to sort signalling complexes in the plasma membrane.

'''PSD-93''' or '''postsynaptic density protein 93''' or '''disks large homolog 2''' is a postneuronic neuronal MAGUK with 3 PDZ domains and can bind to specific ion channels and mediate their clustering<ref>PMID:11312293</ref>.

== Disease ==

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N-methyl-d-aspartate (NMDAR): NMDAR is a second horizontal filament that assists with the structure of the PSD. While one of the most important proteins of the PSD, it is only found near the center with spacing of 30nm. The NMDAR protein makes a rhombic-like framework that provides space for 16-25 receptors in the center. It is the largest protein of all of those in the PSD at a diameter of roughly 130 nm. It is found both within the cytoplasmic side of the membrane and the extracellular side. In both cases, it interacts with two vertical filaments found at each end of the protein. While the intracellular form is met with PSD-95 filaments, the extracellular form is met with very thin and delicate filaments within the synaptic cleft.

This is a ~~sample scene created with SAT to~~ <scene name="/12/3456/Sample/1">color</scene> ~~by Group, and another to make <scene name~~=~~"/12/3456/Sample/2">a transparent representation</scene>~~ of ~~the~~ protein~~. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.~~

This function is to allow for the ability to view each domain group by a different <scene name="/12/3456/Sample/1">color</scene> .

==3D structures of postsynaptic density protein==

[[Postsynaptic density protein 3D structures]]

</StructureSection>

== References ==

[[Category:Topic Page]]

Postsynaptic density protein: Difference between revisions

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@@ Line 1: / Line 1: @@
 == PSD-95 ==
-<StructureSection load='2XKX' size='340' side='right' caption='Apologies, these domains have not been crystalized into one structure yet so the models that will be seen are all individual pieces of the whole molecule. As such this page is more of an over look into the individual pieces of PSD-95 rather than the entirety of PSD-95.=''>
+<StructureSection load='2XKX' size='340' side='right' caption='Rat postsynaptic density protein 95 (PDB code [[2xkx]])' scene=''>
+Apologies, these domains have not been crystallized into one structure yet so the models that will be seen are all individual pieces of the whole molecule. As such this page is more of an over look into the individual pieces of PSD-95 rather than the entirety of PSD-95
 == Function ==
-PSD-95 is a scaffolding protein that is found in the postsynaptic density (PSD) in the excitatory neurons of the cerebral cortex. This protein belongs to the Membrane-associated guanylate kinases (MAGUK) family. The proteins of the MAGUK family have been found to be a key factor in many processes. These processes include the development of tissues, communications between cells, cellular charge activation, and signal transduction between cells just to name a few. <ref> DOI: 10.1038/emboj.2011.428 </ref> PSD-95 permeates the PSD, a large curved protein complex that lines the postsynaptic membrane (PSM) or the cellular interior of a synapse.  This protein complex’s primary function is one of support. It is known to hold not only synaptic receptors in place in the membrane but it holds their respective signaling molecules as well. PSD-95 is integral to the organization of these receptors, as well as the downstream signaling proteins. Due to the scaffolding directive of PSD-95, its structure is actually a series of proteins to make a much larger binding protein complex. PSD-95 not only enriches synaptic transmissions but it is also known to play a major role in synaptic plasticity through the lattice it makes at the synaptic membrane.
+'''PSD-95''' or '''postsynaptic density protein 95''' or '''disks large homolog 4''' is a scaffolding protein that is found in the postsynaptic density (PSD) in the excitatory neurons of the cerebral cortex. This protein belongs to the Membrane-associated guanylate kinases (MAGUK) family. The proteins of the MAGUK family have been found to be a key factor in many processes. These processes include the development of tissues, communications between cells, cellular charge activation, and signal transduction between cells just to name a few. <ref> DOI: 10.1038/emboj.2011.428 </ref> PSD-95 permeates the PSD, a large curved protein complex that lines the postsynaptic membrane (PSM) or the cellular interior of a synapse.  This protein complex’s primary function is one of support. It is known to hold not only synaptic receptors in place in the membrane but it holds their respective signalling molecules as well. PSD-95 is integral to the organization of these receptors, as well as the downstream signalling proteins. Due to the scaffolding directive of PSD-95, its structure is actually a series of proteins to make a much larger binding protein complex. PSD-95 not only enriches synaptic transmissions but it is also known to play a major role in synaptic plasticity through the lattice it makes at the synaptic membrane.
-With PSD-95 being so close to the cell membrane, it can be identified and labeled by antibodies from both sides of the plasma membrane. Due to its location it is able to interact with membrane bound proteins including ion channels, adhesion molecules, and various receptors. The most important of these interactions is considered to be its ability to sort signaling complexes in the plasma membrane.
+With PSD-95 being so close to the cell membrane, it can be identified and labeled by antibodies from both sides of the plasma membrane. Due to its location it is able to interact with membrane bound proteins including ion channels, adhesion molecules, and various receptors. The most important of these interactions is considered to be its ability to sort signalling complexes in the plasma membrane.
+'''PSD-93''' or '''postsynaptic density protein 93''' or '''disks large homolog 2''' is a postneuronic neuronal MAGUK with 3 PDZ domains and can bind to specific ion channels and mediate their clustering<ref>PMID:11312293</ref>.
 == Disease ==
@@ Line 32: / Line 36: @@
 N-methyl-d-aspartate (NMDAR): NMDAR is a second horizontal filament that assists with the structure of the PSD. While one of the most important proteins of the PSD, it is only found near the center with spacing of 30nm. The NMDAR protein makes a rhombic-like framework that provides space for 16-25 receptors in the center. It is the largest protein of all of those in the PSD at a diameter of roughly 130 nm. It is found both within the cytoplasmic side of the membrane and the extracellular side. In both cases, it interacts with two vertical filaments found at each end of the protein. While the intracellular form is met with PSD-95 filaments, the extracellular form is met with very thin and delicate filaments within the synaptic cleft.
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
+This function is to allow for the ability to view each domain group by a different <scene name="/12/3456/Sample/1">color</scene> .
+==3D structures of postsynaptic density protein==
+[[Postsynaptic density protein 3D structures]]
 </StructureSection>
 == References ==
 <references/>
+[[Category:Topic Page]]