Perforin: Difference between revisions

(3 intermediate revisions by 2 users not shown)

Line 1:

==Perforin==

'''Perforin'''

== Function ==

'''Cytolysis/Apoptosis'''

Perforin is a glycoprotein that is responsible for the pore formation of target cells (T-cells) in the cell membranes. Perforin is stored in the lysosome-like secretory granules of cytotoxic T lymphocytes. This protein is utilized by natural killer (NK) cells and CD8-positive T-cells. Perforin can also be expressed in low amounts in CD4-positive T-cells whenever classic cytotoxicity is disrupted. NK cells and T-cells use perforin molecules to create channels that allow for the transport of ions, water, small-molecule substances, and enzymes. By forming these channels, perforin causes problems with the disruptive barrier of the membranes and thus destroys the solidarity of the T-cells. This is why their function can broadly be identified as apoptosis.

'''Perforin''' is a glycoprotein that is responsible for the pore formation of target cells (T-cells) in the cell membranes. Perforin is stored in the lysosome-like secretory granules of cytotoxic T lymphocytes. This protein is utilized by natural killer (NK) cells and CD8-positive T-cells. Perforin can also be expressed in low amounts in CD4-positive T-cells whenever classic cytotoxicity is disrupted. NK cells and T-cells use perforin molecules to create channels that allow for the transport of ions, water, small-molecule substances, and enzymes. By forming these channels, perforin causes problems with the disruptive barrier of the membranes and thus destroys the solidarity of the T-cells. This is why their function can broadly be identified as apoptosis.

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-<Structure load='3NSJ' size='350' frame='true' align='right' caption='X-ray crystal structure of lymphocyte perforin' scene='Insert optional scene name here' />
+<Structure load='3NSJ' size='350' frame='true' align='right' caption='X-ray crystal structure of glycosylated lymphocyte perforin complex with glycerol, Ca+2 (green), I- (purple), Cl- (green) (PDB code [[3nsj]])' scene='Insert optional scene name here' />
-==Perforin==
+'''Perforin'''
 == Function ==
 '''Cytolysis/Apoptosis'''
-Perforin is a glycoprotein that is responsible for the pore formation of target cells (T-cells) in the cell membranes. Perforin is stored in the lysosome-like secretory granules of cytotoxic T lymphocytes. This protein is utilized by natural killer (NK) cells and CD8-positive T-cells. Perforin can also be expressed in low amounts in CD4-positive T-cells whenever classic cytotoxicity is disrupted. NK cells and T-cells use perforin molecules to create channels that allow for the transport of ions, water, small-molecule substances, and enzymes. By forming these channels, perforin causes problems with the disruptive barrier of the membranes and thus destroys the solidarity of the T-cells. This is why their function can broadly be identified as apoptosis.
+'''Perforin''' is a glycoprotein that is responsible for the pore formation of target cells (T-cells) in the cell membranes. Perforin is stored in the lysosome-like secretory granules of cytotoxic T lymphocytes. This protein is utilized by natural killer (NK) cells and CD8-positive T-cells. Perforin can also be expressed in low amounts in CD4-positive T-cells whenever classic cytotoxicity is disrupted. NK cells and T-cells use perforin molecules to create channels that allow for the transport of ions, water, small-molecule substances, and enzymes. By forming these channels, perforin causes problems with the disruptive barrier of the membranes and thus destroys the solidarity of the T-cells. This is why their function can broadly be identified as apoptosis.
+See also [[Cytolysin]].
 == Mechanism ==
@@ Line 17: / Line 19: @@
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
-</StructureSection>
 == References ==
 <Kondos, S. C., et al. “The Structure and Function of Mammalian Membrane-Attack Complex/Perforin-like Proteins.” Tissue Antigens, vol. 76, no. 5, Nov. 2010, pp. 341–351. EBSCOhost, doi:10.1111/j.1399-0039.2010.01566.x.>